Journal of X-Ray Science and Technology - Volume 19, issue 2
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Journal of X-Ray Science and Technology is an international journal designed for the diverse community (biomedical, industrial and academic) of users and developers of novel x-ray imaging techniques. The purpose of the journal is to provide clear and full coverage of new developments and applications in the field.
Areas such as x-ray microlithography, x-ray astronomy and medical x-ray imaging as well as new technologies arising from fields traditionally considered unrelated to x rays (semiconductor processing, accelerator technology, ionizing and non-ionizing medical diagnostic and therapeutic modalities, etc.) present opportunities for research that can meet new challenges as they arise.
Abstract: Glycated chitosan (GC) is a new compound derived from chitosan by attaching galactose molecules to the chitosan molecules. GC was designed for immune stimulations in combination with phototherapies in the cancer treatment. The future clinical applications require a thorough understanding of the properties of GC. Murine macrophage cells (RAW264.7) were used to investigate NO formation and TNFα secretion stimulated by GC. Murine mammary tumor cells (EMT6) were treated in vitro and in vivo by laser irradiation…with 980 nm in combination with GC stimulation. Here is the first in a series of studies designed to understand the immunological mechanisms of GC. Our in vitro results show that GC could enter into macrophages to stimulate NO generation and TNFα secretion. GC could further enhance the TNFα secretion of macrophages stimulated by laser treated tumor cells. Our in vivo results also show immunological effects of GC, particularly in inducing tumor-specific immune responses. Our results indicated that GC was a strong immunological stimulant for cancer treatment, particularly when combined with laser phototherapies.
Keywords: Glycated chitosan, cancer treatment, immunological mechanisms, macrophages