Journal of X-Ray Science and Technology - Volume 15, issue 2
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Impact Factor 2023: 3
Journal of X-Ray Science and Technology is an international journal designed for the diverse community (biomedical, industrial and academic) of users and developers of novel x-ray imaging techniques. The purpose of the journal is to provide clear and full coverage of new developments and applications in the field.
Areas such as x-ray microlithography, x-ray astronomy and medical x-ray imaging as well as new technologies arising from fields traditionally considered unrelated to x rays (semiconductor processing, accelerator technology, ionizing and non-ionizing medical diagnostic and therapeutic modalities, etc.) present opportunities for research that can meet new challenges as they arise.
Abstract: A Zernike-type phase contrast hard X-ray microscope was constructed at Photon Factory (PF) BL3C2. The spatial resolution of better than 200 nm was obtained with the zone plate of the outermost zone width of 50 nm at the X-ray energy of 5 keV. A pinhole-type phase plate was made of 3μm thick aluminum foil. Transparent biological specimens could be observed. A phase contrast three dimensional image was obtained using a tomographic technique.
Keywords: Phase contrast, hard X-ray microscope, zone plate, tomography
Abstract: As a novel imaging method, X-ray diffraction enhanced imaging (DEI) has extremely high sensitivity for weakly absorbing biological soft tissues. Recently, biomedical application research about DEI and computed tomography of DEI (DEI-CT) has become a hot issue. In this paper, a novel visualization method of micro biomedical structures is presented, which uses DEI-CT techniques to study guinea pig cochleae. The acquired DEI images clearly displayed the spiral structures and inner details of the guinea pig cochleae.…DEI-CT reconstructions were obtained from the peak projection data and refraction angle projection data of guinea pig cochleae. Based on DEI-CT reconstructions, we implemented three-dimensional visualization of guinea pig cochleae. Moreover, visualization of guinea pig cochlea based on color images of the histological sections was performed for comparison with the results of DEI-CT. The advantages and limitations of the two methods in visualizing guinea pig cochleae are also discussed. This study demonstrates that DEI-CT is an effective method to visualize the biomedical micro-organs and minute tissues with a good contrast and spatial resolution.
Abstract: In this work we study the robustness of a phase-retrieval approach, which is based on the phase-attenuation duality. We discuss the critical importance of retrieval robustness for diagnostic imaging in perspective of the radiation dose limit and lesion-detection sensitivity. We compare the robustness of duality-based phase retrieval with that of the transport of intensity equation (TIE)-based phase-retrieval approach, and we show by means of simulation that the duality-based retrieval approach is superior to the…TIE-based approach. A generalization of TIE per se is presented for incorporating the coherence degree of incident x-ray wavefield.
Abstract: To evaluate the value of phase contrast x-ray imaging (PCI) with a synchrotron radiation (SR) source in which we performed hepatic imaging in the 4W1A beamline of Beijing Synchrotron Radiation Facility (BSRF). The hepatic specimens from a SD mouse, a normal adult and a biliary cirrhosis patient were imaged with the diffraction enhanced imaging (DEI) technique. We showed that the three grade vessel branches in the mouse, the hepatic lobule of the normal adult and the…enlarged bile ducts of the biliary cirrhosis patient could all be clearly revealed with the DEI technique. Our results indicated that the PCI techniques including DEI might improve hepatic imaging performance in spatial resolution and tissue contrast.