Journal of Pediatric Neurology - Volume 9, issue 3
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Journal of Pediatric Neurology is an English multidisciplinary peer-reviewed medical journal publishing articles in the fields of child neurology, pediatric neurosurgery, pediatric neuroradiology, child psychiatry and pediatric neuroscience.
Journal of Pediatric Neurology encourages submissions from authors throughout the world. The following articles will be considered for publication: editorials, original and review articles, rapid communications, case reports, letters to the editor and book reviews. The aim of the journal is to share and disseminate knowledge between all disciplines that work in the field of pediatric neurology.
Abstract: Dandy-Walker syndrome (DWS), or Dandy-Walker complex, is a congenital brain malformation of the posterior fossa, typically resulting in developmental delay and cognitive disability. The co-occurrence of Down syndrome (DS) and DWS is relatively uncommon; thus, its impact on developmental outcomes has not been fully elucidated. Herein, we report a case of a 37-month-old child with DS and DWS, who is functioning at the following age-equivalent: gross motor at a 9-mo level, fine motor 6 mo, expressive…language 14 mo, receptive language 9 mo. As such, it is important to determine how the DWS influences developmental outcomes, and appreciate the importance of early interventional therapy.
Keywords: Down syndrome, Dandy-Walker syndrome, developmental outcomes
Abstract: Early myoclonic encephalopathy (EME) is an epileptic encephalopathy characterized by highly refractory seizures and an overall bad prognosis. In this report, we present an infant who developed EME secondary to nonketotic hyperglycinemia. A vagus nerve stimulator inserted when the infant was 6 months and 3-weeks-old resulted in mild psychomotor improvement and in a dramatic reduction in seizure frequency documented by closed-circuit television-electroencephalography monitoring. This is the youngest infant in the literature reported…so far inserted with a vagus nerve stimulator, and the results suggest that this treatment modality is safe and can be of benefit in reducing seizures associated with EME.
Keywords: Vagal nerve stimulation, early myoclonic encephalopathy, nonketotic hyperglycinemia
Abstract: We report a case of thalamic mixed germ cell tumor of in a 13-year-old boy. The boy presented with headache, generalized seizures and right-sided paresis of recent onset. Computed tomography and magnetic resonance imaging revealed a mass in the left thalamus with hydrocephalus. The histopathological examination of operated mass showed an immature teratoma with large areas of germinomatous components. The predominant components of immature teratoma were composed of several types of tissue representing different…germinal layers (endoderm, mesoderm and ectoderm) and showing varying degrees of differentiation. This was diagnosed as a mixed germ cell tumor. A subgroup of tumor secretes specific tumor markers, including α-fetoprotein and β-human chorionic gonadotrophin, which may be helpful in pre-operative diagnosis. Germinomas most often occur in pineal or supraseller region but occasionally develop in highly unusual locations like the thalamus. Those presenting in unusual locations pose a diagnostic challenge. Pre-operative diagnosis, however, may change the line of management.
Abstract: Facial nerve paralysis in childhood is commonly caused by acute ear infections and Lyme disease. A number of respiratory viruses have also been associated with acute facial nerve weakness. First described as a common cause of respiratory infection in 2001, human metapneumovirus has now also been associated with abnormalities of the central nervous system, such as seizures and encephalitis. We describe a case of acute facial nerve palsy in which human metapneumovirus was the only pathogen…identified, using sophisticated molecular diagnostics.
Keywords: Human metapneumovirus, facial nerve palsy, rapid diagnostics, resequencing microarray