Journal of Pediatric Neurology - Volume 7, issue 1
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Journal of Pediatric Neurology is an English multidisciplinary peer-reviewed medical journal publishing articles in the fields of child neurology, pediatric neurosurgery, pediatric neuroradiology, child psychiatry and pediatric neuroscience.
Journal of Pediatric Neurology encourages submissions from authors throughout the world. The following articles will be considered for publication: editorials, original and review articles, rapid communications, case reports, letters to the editor and book reviews. The aim of the journal is to share and disseminate knowledge between all disciplines that work in the field of pediatric neurology.
Abstract: Novel medications to treat neonatal seizures have been the subject of numerous recent basic science research and clinical papers describing the potential and need for more effective and safe antiepileptic drugs (AEDs) for this unique population. This interest has been fueled in part by the notion that seizures, particularly when refractory, likely contribute to brain injury, later epilepsy and neurodevelopmental impairments. The population of newborns with seizures presents unique challenges, because of the often significant…differences in the pharmacokinetics, safety and efficacy of medications when compared with older children and adults. Bumetanide and topiramate are two novel AEDs that have mechanisms of action uniquely suited to suppressing seizures in the newborn brain, with promising basic science data supporting their use in human newborns. Furthermore, these novel medications offer the potential of neuroprotective effects when used to treat refractory seizures caused by acute insults to the neonatal brain. The available data regarding the mechanism of action, pharmacokinetics, and safety of these two AEDs will be described, as well as the data needed to bring these two agents into routine use in the human newborn with seizures.
Abstract: The treatment of infants with antiepileptic medications after the resolution of neonatal seizures is highly variable and controversial. Infants are commonly treated with phenobarbital after their seizures have resolved to prevent recurrence. Data to support this practice are lacking but animal models suggest that the neonatal brain is vulnerable to repeated seizures. Yet exposure of the developing brain to phenobarbital for prolonged periods may have deleterious consequences. We discuss current clinical practice and present…information on risks and benefits of continued treatment with phenobarbital after resolution of neonatal seizures.
Keywords: Phenobarbital, neonate, seizures, brain development