Journal of Pediatric Neurology - Volume 5, issue 3
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Journal of Pediatric Neurology is an English multidisciplinary peer-reviewed medical journal publishing articles in the fields of child neurology, pediatric neurosurgery, pediatric neuroradiology, child psychiatry and pediatric neuroscience.
Journal of Pediatric Neurology encourages submissions from authors throughout the world. The following articles will be considered for publication: editorials, original and review articles, rapid communications, case reports, letters to the editor and book reviews. The aim of the journal is to share and disseminate knowledge between all disciplines that work in the field of pediatric neurology.
Abstract: Diffusion-weighted magnetic resonance images and brain blood perfusion scintigraphy are useful tools in identifying the cause of cerebral lesions. We report serial simultaneous diffusion-weighted magnetic resonance images and brain blood perfusion scintigraphy of hemiconvulsion-hemiplegia-epilepsy syndrome. In this case, the involved hemisphere revealed high intensity on diffusion-weighted images and slight hyperperfusion on brain blood perfusion scintigraphy 7 days after the seizure. Accordingly, neurotoxic, rather than ischemic, cellular edema might be the…cause of hemiconvulsion-hemiplegia-epilepsy syndrome in the acute phase.
Abstract: Intrathecal therapy with methotrexate and cytosine-arabinoside is a therapeutic strategy for maintaining remission in patients with acute lymphoblastic leukemia, that is associated with neurological side effects are described. We report a 4-year-old girl who became tetraplegic after the last dose of intrathecal therapy. Cerebrospinal fluid showed elevated protein level and nerve conduction study revealed a motor neuronopathy. Spine magnetic resonance imaging revealed gadolinium enhancement of the anterior roots of the cauda equina.…We describe a myelopathy confined to the anterior horns and anterior spinal nerve roots without sensory involvement caused by intrathecal methotrexate. The pathogenesis of this selective involvement remains uncertain.
Keywords: Intrathecal methotrexate, acute lymphocytic leukemia, motor neuronopathy, ventral polyradiculopathy
Abstract: We describe a rare case of the spinal cord compression by a primary Ewing sarcoma of the thoracolumbar spine. A 16-year-old boy was admitted with back pain for 2 month and inability to walk for 15 days. At the presentation, he had paraparesis and bilateral hypoesthesia below the T12 level, without sphincter dysfunction. Thoracolumbar spine magnetic resonance imaging showed an involved vertebral body mass of the L1 extending in the epidural space with an extension into…the prevertebral area. The mass was totally removed by the anterolateral approach. Histopathological examination revealed Ewing sarcoma. Although his infrequency, such a primary Ewing sarcoma of the vertebral column should be suspected for lesion causing a spinal cord compression particularly in the children and adolescent that the treatment protocol included a three main modalities: surgery, radiotherapy and chemotherapy.
Keywords: Vertebra, Ewing sarcoma, imaging, surgery
Abstract: The authors describe a case of a 12-year-old female with an intra-ventricular cysticercal cyst in the third ventricle, which migrated to left occipital horn during surgical evacuation. The present case highlights the utility of magnetic resonance imaging over computed tomography and role of early postoperative magnetic resonance imaging to rule out the possibility of cyst migration and treatment failure.
Keywords: Intraventricular neurocysticercosis, magnetic resonance imaging, migration
Abstract: Patients with cyanotic heart disease frequently suffer from brain abscesses. While most of such patients are treated conservatively, different modalities of surgical treatments are adapted depending upon the clinical situation. Though pulmonary tuberculosis is reported to be 2.5 times more common in children suffering from congenital heart disease than the general population of the same community, it is not known whether tuberculoma of brain is more common amongst them. Very few cases have been published reporting…tuberculoma brain in patients with cyanotic heart disease. We report a case of cyanotic heart disease, which was treated as a case of bacterial endocarditis and later on suspected to have brain abscess until the patient deteriorated and became comatose requiring craniotomy. Tissue diagnosis of the lesion was tuberculoma. This observation necessitates the need for consideration of tuberculoma of brain in patients suffering from cyanotic heart diseases with neurological signs. Tuberculoma brain is medically treatable with good prognosis, if diagnosed early.
Abstract: Guillain-Barré syndrome (GBS) is an acute inflammatory, demyelinating polyradiculoneuropathy. The neurological complications of varicella-zoster virus (VZV) infection are usually cerebellar ataxia and other forms of encephalitis. VZV is associated with only 1% of the GBS cases. GBS may present as a clinical picture mimicking encephalitis. We report a patient with GBS who presented with altered consciousness and flaccid paralysis of the legs, three weeks after VZV infection.