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The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease.
The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.
Article Type: Research Article
Abstract: The present article reviews the roles and interactions of iron and neuroinflammation in Alzheimer's disease. It highlights the importance of neuroinflammatory changes in the glial scar after neuronal injury, in promoting iron accumulation, and iron-dependent oxidative damage. Elevation of iron in Alzheimer's disease not only affects amyloid precursor protein processing and mitochondrial function but also induces the aggregation of Aβ peptide and abnormalities in signal transduction processes associated with oxidative damage. Collective evidence suggests that although alterations in iron homeostasis may not be the primary triggering event that starts the pathological cascade of Alzheimer's disease, it is an important factor …involved in neuroinflammation and progression of this disease. Show more
Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 183-200, 2005
Article Type: Research Article
Abstract: AβPP is involved in Cu homeostasis in mouse and man. In vitro observations and in vivo data obtained from AβPP mouse models at least provide strong evidence that AβPP and Aβ overproduction enables intracellular Cu to be transported out of the cell. The increased Cu efflux seems to lead to a Cu deficiency and a subsequently reduced SOD-1 activity. Studies have shown that a disturbed metal-ion homeostasis with elevated serum Cu levels occurs in Alzheimer and Down's patients and lowered levels in post-mortem AD brain. We conclude that bioavailable Cu has beneficial and specific effects in Alzheimer's disease transgenic mice, …and suggest that our observation can be regarded as a proof-of-concept for a prophylactic approach to overcome the observed CNS Cu deficiency in the brain of Alzheimer's disease patients. Show more
Keywords: AβPP, Alzheimer's disease, Cu deficiency, amyloid, pathology, transgenic model, SOD-1
Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 201-206, 2005
Article Type: Discussion
Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 209-215, 2005
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