Journal of Alzheimer's Disease - Volume 8, issue 2

Authors: Ong, Wei-Yi | Farooqui, Akhlaq A.

Article Type: Research Article

Abstract: The present article reviews the roles and interactions of iron and neuroinflammation in Alzheimer's disease. It highlights the importance of neuroinflammatory changes in the glial scar after neuronal injury, in promoting iron accumulation, and iron-dependent oxidative damage. Elevation of iron in Alzheimer's disease not only affects amyloid precursor protein processing and mitochondrial function but also induces the aggregation of Aβ peptide and abnormalities in signal transduction processes associated with oxidative damage. Collective evidence suggests that although alterations in iron homeostasis may not be the primary triggering event that starts the pathological cascade of Alzheimer's disease, it is an important factor …involved in neuroinflammation and progression of this disease. Show more

DOI: 10.3233/JAD-2005-8211

Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 183-200, 2005

Authors: Bayer, Thomas A. | Multhaup, Gerd

Article Type: Research Article

Abstract: AβPP is involved in Cu homeostasis in mouse and man. In vitro observations and in vivo data obtained from AβPP mouse models at least provide strong evidence that AβPP and Aβ overproduction enables intracellular Cu to be transported out of the cell. The increased Cu efflux seems to lead to a Cu deficiency and a subsequently reduced SOD-1 activity. Studies have shown that a disturbed metal-ion homeostasis with elevated serum Cu levels occurs in Alzheimer and Down's patients and lowered levels in post-mortem AD brain. We conclude that bioavailable Cu has beneficial and specific effects in Alzheimer's disease transgenic mice, …and suggest that our observation can be regarded as a proof-of-concept for a prophylactic approach to overcome the observed CNS Cu deficiency in the brain of Alzheimer's disease patients. Show more

Keywords: AβPP, Alzheimer's disease, Cu deficiency, amyloid, pathology, transgenic model, SOD-1

DOI: 10.3233/JAD-2005-8212

Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 201-206, 2005

Authors: Sensi, Stefano L. | van Rensburg, Susan

Article Type: Meeting Report

DOI: 10.3233/JAD-2005-8213

Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 207-208, 2005

Article Type: Discussion

DOI: 10.3233/JAD-2005-8214

Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 209-215, 2005

Article Type: Book Review

DOI: 10.3233/JAD-2005-8215

Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 217-217, 2005

Article Type: Announcement

DOI: 10.3233/JAD-2005-8216

Citation: Journal of Alzheimer's Disease, vol. 8, no. 2, pp. 219-222, 2005