Journal of Alzheimer's Disease - Volume 30, issue 4

Authors: Herring, Arne | Donath, Anja | Steiner, Katharina M. | Widera, Manuel P. | Hamzehian, Samira | Kanakis, Dimitrios | Kölble, Konrad | ElAli, Ayman | Hermann, Dirk M. | Paulus, Werner | Keyvani, Kathy

Article Type: Research Article

Abstract: Alterations in the expression of Reelin (RELN) have been implicated in the pathology of Alzheimer's disease (AD). However, whether these changes are cause or consequence of AD remains to be resolved. To better understand the role of RELN pathway in the development of AD, we examined the expression profile of RELN and its downstream signaling members APOER2, VLDLR, and DAB1 in AD-vulnerable regions of transgenic and wildtype mice as well as in AD patients and controls across disease stages and/or aging. We show that both AD pathology and aging are associated with perturbation of the RELN pathway in a species-, …region-, and molecule-specific manner. Further, we show that depletion of RELN, but not its downstream signaling molecules, is detectable long before the onset of amyloid-β pathology in the murine hippocampus and in a pre-clinical AD stage in the human frontal cortex. This early event hints at a possible causative role of RELN decline in the precipitation of AD pathology and supports RELN's potential as a pre-clinical marker for AD. Show more

Keywords: Alzheimer's disease, APOER2, DAB1, human, reelin, TgCRND8, VLDLR

DOI: 10.3233/JAD-2012-112069

Citation: Journal of Alzheimer's Disease, vol. 30, no. 4, pp. 963-979, 2012

Authors: Ventriglia, Mariacarla | Bucossi, Serena | Panetta, Valentina | Squitti, Rosanna

Article Type: Correction

Abstract: This contribution reviews and corrects data from our previous meta-analysis, which appeared in the Journal of Alzheimer's Disease in 2011 concerning the role of copper in Alzheimer's disease. We repeated the meta-analysis after excluding four of the five studies from our laboratory to avoid possible bias in the result. In addition, we included two studies on serum copper levels in Alzheimer's disease not previously considered. The results indicate higher levels of copper in Alzheimer's disease patients than in controls, confirming our previous conclusion.

Keywords: Alzheimer's disease, copper, meta-analysis, serum

DOI: 10.3233/JAD-2012-120244

Citation: Journal of Alzheimer's Disease, vol. 30, no. 4, pp. 981-984, 2012

Article Type: Other

DOI: 10.3233/JAD-2012-120245

Citation: Journal of Alzheimer's Disease, vol. 30, no. 4, pp. 985-987, 2012

Article Type: Other

DOI: 10.3233/JAD-2012-30424

Citation: Journal of Alzheimer's Disease, vol. 30, no. 4, pp. 989-998, 2012