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Impact Factor 2020: 3.909
The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease.
The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.
Authors: Herring, Arne | Donath, Anja | Steiner, Katharina M. | Widera, Manuel P. | Hamzehian, Samira | Kanakis, Dimitrios | Kölble, Konrad | ElAli, Ayman | Hermann, Dirk M. | Paulus, Werner | Keyvani, Kathy
Article Type: Research Article
Abstract: Alterations in the expression of Reelin (RELN) have been implicated in the pathology of Alzheimer's disease (AD). However, whether these changes are cause or consequence of AD remains to be resolved. To better understand the role of RELN pathway in the development of AD, we examined the expression profile of RELN and its downstream signaling members APOER2, VLDLR, and DAB1 in AD-vulnerable regions of transgenic and wildtype mice as well as in AD patients and controls across disease stages and/or aging. We show that both AD pathology and aging are associated with perturbation of the RELN pathway in a species-, …region-, and molecule-specific manner. Further, we show that depletion of RELN, but not its downstream signaling molecules, is detectable long before the onset of amyloid-β pathology in the murine hippocampus and in a pre-clinical AD stage in the human frontal cortex. This early event hints at a possible causative role of RELN decline in the precipitation of AD pathology and supports RELN's potential as a pre-clinical marker for AD. Show more
Keywords: Alzheimer's disease, APOER2, DAB1, human, reelin, TgCRND8, VLDLR
Citation: Journal of Alzheimer's Disease, vol. 30, no. 4, pp. 963-979, 2012
Article Type: Correction
Abstract: This contribution reviews and corrects data from our previous meta-analysis, which appeared in the Journal of Alzheimer's Disease in 2011 concerning the role of copper in Alzheimer's disease. We repeated the meta-analysis after excluding four of the five studies from our laboratory to avoid possible bias in the result. In addition, we included two studies on serum copper levels in Alzheimer's disease not previously considered. The results indicate higher levels of copper in Alzheimer's disease patients than in controls, confirming our previous conclusion.
Keywords: Alzheimer's disease, copper, meta-analysis, serum
Citation: Journal of Alzheimer's Disease, vol. 30, no. 4, pp. 981-984, 2012
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