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The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease.
The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.
Authors: Dosunmu, Remi | Wu, Jinfang | Adwan, Lina | Maloney, Bryan | Basha, Md. Riyaz | McPherson, Christopher A. | Harry, G. Jean | Rice, Deborah C. | Zawia, Nasser H. | Lahiri, Debomoy K.
Article Type: Research Article
Abstract: Alzheimer's disease (AD) is characterized by plaques of amyloid-β (Aβ) peptide, cleaved from amyloid-β protein precursor (AβPP). Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AβPP mRNA, AβPP protein, and Aβ levels in rodents and primates. We also tracked a transcriptional regulator of the AβPP gene, specificity protein 1 (SP1), and the β amyloid precursor cleaving enzyme (BACE1). In mice, AβPP and SP1 mRNA and their protein products were elevated late in …life; Aβ levels declined in old age. In monkeys, SP1, AβPP, and BACE1 mRNA declined in old age, while protein products and Aβ levels rose. Proteolytic processing in both species did not match production of Aβ. In primates, AβPP and SP1 mRNA levels coordinate, but an inverse relationship exists with corresponding protein products as well as Aβ levels. Comparison of human DNA and mRNA sequences to monkey and mouse counterparts revealed structural features that may explain differences in transcriptional and translational processing. These findings are important for selecting appropriate models for AD and other age-related diseases. Show more
Keywords: Amyloid-β protein precursor (AβPP), amyloidogenesis, BACE1, development, primates, rodents, specificity protein 1 (SP1), transcription
DOI: 10.3233/JAD-2009-1138
Citation: Journal of Alzheimer's Disease, vol. 18, no. 1, pp. 211-230, 2009
Authors: Casadesus, Gemma
Article Type: Book Review
DOI: 10.3233/JAD-2009-1131
Citation: Journal of Alzheimer's Disease, vol. 18, no. 1, pp. 231-232, 2009
Authors: Landhuis, Esther
Article Type: Research Article
DOI: 10.3233/JAD-2009-1176
Citation: Journal of Alzheimer's Disease, vol. 18, no. 1, pp. 233-239, 2009
Article Type: Announcement
DOI: 10.3233/JAD-2009-1172
Citation: Journal of Alzheimer's Disease, vol. 18, no. 1, pp. 241-242, 2009
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