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The Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease.
The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer’s disease.
Authors: Sato, Noriko | Ueki, Akinori | Ueno, Hideo | Shinjo, Hidetaka | Morita, Yoshio
Article Type: Research Article
Abstract: Dopamine D3 receptor (DRD3) is present in the limbic system, which is thought to regulate affect, cognition, and activity. Thus a functional change in the DRD3 gene could in turn affect the cognitive and psychiatric symptoms of dementia of Alzheimer's type (DAT). We investigated a possible association of DRD3 genotype with DAT and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for DRD3 and apolipoprotein E (ApoE) was determined using restriction fragment length polymorphism in 210 patients with mild DAT and 224 age- and sex-matched non-demented controls. The occurrence of BPSD during the course of …mild dementia was demonstrated using the Behavioral Pathology in Alzheimer's Disease rating scale (BEHAVE-AD). No significant differences in DRD3 genotype were identified between DAT and controls, regardless of ApoE ε4. Among the DAT with BPSD, however, a significant association was observed between the presence of the DRD3 glycine allele and paranoid and delusional ideation, regardless of ApoE ε4. In conclusion, DRD3 gene polymorphism is unlikely to play a substantial role in conferring susceptibility to DAT, but it may be involved in the development of paranoid and delusional ideation during the course of mild DAT. Show more
Keywords: Behavioral and psychological symptoms of dementia (BPSD), delusional ideation, dementia of Alzheimer's type, dopamine D3 receptor, gene polymorphism, paranoid ideation, Ser9Gly
DOI: 10.3233/JAD-2009-1054
Citation: Journal of Alzheimer's Disease, vol. 17, no. 2, pp. 441-448, 2009
Article Type: Discussion
DOI: 10.3233/JAD-2009-1085
Citation: Journal of Alzheimer's Disease, vol. 17, no. 2, pp. 449-452, 2009
Article Type: Announcement
DOI: 10.3233/JAD-2009-1102
Citation: Journal of Alzheimer's Disease, vol. 17, no. 2, pp. 453-455, 2009
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