Journal of Alzheimer's Disease - Volume 13, issue 3

Authors: Xu, Yanan | Cao, Zhiming | Khan, Ikhlas | Luo, Yuan

Article Type: Research Article

Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that shows cognitive deficits and memory impairment. Extract from the leaves of Gotu Kola (Centella Asiatica) have been used as an alternative medicine for memory improvement in Indian Ayurvedic system of medicine for a long time. Although several studies have revealed its effect in ameliorating the cognitive impairment in rat models of AD and stimulating property on neuronal dendrites of hippocampal region, the molecular mechanism of Gotu Kola on neuroprotection still remains to be elucidated. In this study, we report that phosphorylation of cyclic AMP response element binding protein (CREB) is enhanced …in both a neuroblastoma cell line expressing amyloid beta 1–42 (Aβ) and in rat embryonic cortical primary cell culture. In addition, the contribution of two major single components to the enhanced CREB phosphorylatioin was examined. Furthermore, inhibitors were applied in this study revealing that ERK/RSK signaling pathway might mediate this effect of Gotu Kola extract. Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time. Show more

DOI: 10.3233/JAD-2008-13311

Citation: Journal of Alzheimer's Disease, vol. 13, no. 3, pp. 341-349, 2008

Article Type: Book Review

DOI: 10.3233/JAD-2008-13312

Citation: Journal of Alzheimer's Disease, vol. 13, no. 3, pp. 351-351, 2008

Article Type: Announcement

DOI: 10.3233/JAD-2008-13313

Citation: Journal of Alzheimer's Disease, vol. 13, no. 3, pp. 353-355, 2008