Clinical Hemorheology and Microcirculation - Volume 7, issue 2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: The effect of pentoxifylline (PTX) on red blood cell-endothelial cell adherence was studied for sickle and normal red blood cells (RBC). Human umbilical vein endothelial cells grown to confluence on glass slides formed the base of a parallel plate flow chamber into which RBC suspensions were perfused at a constant flow rate, producing a wall shear stress of 1 dyne/cm2 . RBC were incubated with PTX at 37°C for one hour at concentrations ranging from 0.1 to 10.0 mmol/L. Adhesion was monitored using video microscopy. The number of adherent RBC was determined at 10-minute intervals during a wash-out period which…followed a 10-minute perfusion of red cells. When compared with unincubated control RBC, the adherence of sickle RBC incubated with 0.1, 1.0 and 10.0 mmol/L of pentoxifylline was reduced to 65%, 53% and 39% of control values, respectively. There was no significant difference between the adherence of drug incubated and untreated normal RBC. These results indicate that pentoxifylline significantly affects the adhesion of sickle RBC to cultured human endothelial cells, but has no effect on the adherence of normal RBC.
Keywords: Pentoxifylline, sickle cells, endothelial cells, adherence, video microscopy
Abstract: The electrophoretic mobility of erythrocytes from patients with primary Raynaud’s phenomenon was measured in near physiological strength saline using laser Doppler microelectrophoresis and has been shown not to be significantly different from that of matched normal controls. It was found that washing the erythrocytes caused a significant, but small, increase in mobility of up to 3.5%. Two anticoagulation procedures, defibrination and heparinization, were compared and found not to affect measured mobility.