Clinical Hemorheology and Microcirculation - Volume 6, issue 6
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: A new instrument (Radial Spreading Rheometer) has been deve loped to measure the radial spreading time of a concentrated washed erythrocyte suspension through a horizontally suspended filter paper. A calibration time (CT) for radial spreading of buffer was used to calibrate individual filter papers. The radial spreading time (RST) for washed erythrocytes was then expressed as the ratio RST/CT and adjusted to a standard packed cell volume of 0.50 (50%). The ratio RST/CT was independent of (a) temperature within the range 20–35°C, (b) leucocyte count up to 5.0 × 109 /l, and (c) platelet count up to 76 × 109…/l. The ratio RST/CT correlated significantly (r = 0.418, P < 0.05) with erythrocyte mean cell haemoglobin concentration but not with mean cell volume. Radial spreading rheometry is a low-cost technique for measuring erythrocyte deformability by bulk flow of a concentrated cell suspension through the wide channels of paper filters.
Abstract: Four rheological instruments for measuring erythrocyte deformability have been compared. Erythrocyte filterability was measured by a Hemorheometre and a St. George’s Filtrometer, erythrocyte viscosity by a Contraves LS 30 rotational viscometer, and erythrocyte radial spreading in filter paper by a Radial Spreading Rheometer. Each instrument showed adequate reproducibility, giving coefficients of variation for 10 replicate samples of < 5.5%. As in the case of other filtration instruments, the St. George’s Filtrometer was sensitive to leucocyte contamination of the erythrocyte suspension. When leucocyte-depleted erythrocytes were manipulated in vitro to give an incremental loss of deformability ranging from < 10% to >…100%, the St. George’s Filtrometer was found to be the most sensitive of the four instruments in six of eight test models. The different relative sensitivities of these instruments should now be evaluated in clinical studies.
Abstract: A viscometric study of blood from insulin-treated diabetics separated into three clini.cal groups (without retinopathy, with minimal retinopathy and with moderate or severe retinopathy) has been carried on. Among the studied viscometric parameters, three of them, relative to red blood cells (RBC) aggregation, have been found to be more modified in patients with retinopathy than in those without. The results involve (i) a more difficult break off of the blood structure, (ii) a more rigid network structure, (iii) a strong trouble of the rouleaux disaggregation process. These modifications are found closely linked to plasmatic disorders. Furthermore, the deformability of diabetic…RBC, evaluated by viscometry is found decreased.
Abstract: This paper reports on a new microscopic method for measuring the deformability of erythrocytes. A 0.3 ml specimen of capillary blood was washed and a portion of the erythrocyte suspension was placed on a microscope slide. After sedimentation the erythrocytes adhered to the glass surface as a monolayer. The slide was placed in a flow chamber and the adhered erythrocytes were deformed due to the shear force caused by the introduction of a transverse flow. During deformation transmission of monochromatic light and length to width ratio of the deformed cells were measured. There was a positive relationship between light transmission…and erythrocyte shape change. This new method was tested by measuring the effect of changes in shear stress, pH and osmotic pressure on erythrocyte deformability. It was concluded that this method is adequately sensitive to measure the influence of low shear stresses and variation of pH and osmotic pressure on the deformability of erythrocytes and was not influenced by the presence of white cells or platelets.