Clinical Hemorheology and Microcirculation - Volume 6, issue 2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: The influence of different molecular weight dextrans (MW: 6000, 10 000, 40 000, 70 000), hydroxyethyl starch, gelatine and albumin on plasma viscosity, apparent whole blood viscosity and erythrocyte flexibility was studied in vitro. Compared to blood samples two hours incubated with Ringers solution alone, dextrans of 40 000 and 70 000 molecular weight caused the most pronounced increase in plasma viscosity, erythrocyte aggregation and decrease in erythrocyte flexibility. For albumin, hydroxyethyl starch and gelatine these effects were less, but still significant in comparison to the control measurements. The commercially available dextran solutions for clinical use vary widely with…respect to their molecular weight (MW distribution: > 90% of the total amount within the range of 10 000–80 000). It has also been demonstrated, that the high molecular weight components are excreted at a lower rate, which leads to an increase of plasma concentration during repeated infusions (ARTURSON 1954, (1)). The results of our in vitro study support the hypothesis that the increase in apparent whole blood viscosity after repeated infusions, as demonstrated in several clinical experiments is due to an increase of higher molecular weight components, which accumulate in plasma during prolonged infusions with LMWD.
Abstract: We have studied the acute effects of smoking two cigarettes with a high nicotine content in young healthy smokers. The haemorheological profile (blood and plasma viscosity and blood filterability), the peripheral haemodynamics (blood flow in the limbs, at rest and during reactive postischemic hyperemia using a strain gauge plethysmograph) and the metabolic pattern (acid-base balance, oxymetric values and COHb) have been evaluated before and after smoking. Results have shown that cigarette smoking provokes besides an evident increase of COHb, a decrease of blood filterability and an impairment of the last phase of the reactive hyperemia with the lenghtening of the…total time. These data suggest that a possible impairment of the blood flow at microcirculatory level can occur in these subjects after cigarette smoking.
Abstract: The viscoelastic behavior of coagulating plasma and whole blood were examined in a modified thrombelastograph. We found that platelets greatly increased the measured rigidity of coagulating blood and plasma, and this rigidity was augmented by erythrocytes. Red cells also slowed the rate of stiffening, which may be due to the red cell membrane activity. In whole blood, the relaxation of stress at constant strain demonstrated a biphasic pattern: the early rapid phase depended on the primary orientation of fibrin into a network by platelets and red cells. The second slower phase was dependent on Factor XIII activity in secondary rearrangement…of the network. Crosslinking of fibrin by Factor XIII had little effect on rigidity.