Clinical Hemorheology and Microcirculation - Volume 4, issue 2-3
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: The maleimide-analogue sulfhydryl spin label MAL-6 has been used to study the motional and structural behavior of erythrocyte membrane proteins. Erythrocyte ghosts from insulin-dependent diabetic patients with long-standing complications were mainly examined. The ratios of weakly- and strongly- immobilized -SH groups were valued from the ESR spectra. The results indicate a high degree of resistance of the erythrocyte membrane to rapid bending rather than an increased resistance to translational motion.
Abstract: Decreased blood filterability has been found in intermittent claudicants, compared to age matched controls. An analysis of the initial filtration rate and of filter plugging showed: 1. Decreased filterability was caused essentially by filter clogging, rather than by change of initial filtration rate. 2. The remaining white cells in the suspension play a significant role in the plugging of the filter, however they cannot be held responsible for all the plugging observed. 3. Filtration tests measuring more than 0.1–0.2 ml suspension of 0.05 haematocrit are more sensitive to filter plugging than to red cell passage time. 4.…The measurement of red cell deformability (defined as transit time through a 5 µm pore) requires more sensitive methods than any of those used so far in clinical studies. 5. The white cell count in the buffy coat depleted blood was related to the plasma viscosity but not to the white cell count in the original whole blood, suggesting significant differences in cell adherence which might be an important factor 1n blood filterability. Decreased filterability was caused essentially by filter clogging, rather than by change of initial filtration rate. The remaining white cells in the suspension play a significant role in the plugging of the filter, however they cannot be held responsible for all the plugging observed. Filtration tests measuring more than 0.1–0.2 ml suspension of 0.05 haematocrit are more sensitive to filter plugging than to red cell passage time. The measurement of red cell deformability (defined as transit time through a 5 µm pore) requires more sensitive methods than any of those used so far in clinical studies. The white cell count in the buffy coat depleted blood was related to the plasma viscosity but not to the white cell count in the original whole blood, suggesting significant differences in cell adherence which might be an important factor 1n blood filterability.
Keywords: red cell filterability, red cell deformability, filter plugging, cell adherence
Abstract: The haemorheological traits were studied in 129 alcoholic liver diseases, 19 alcoholic patients without liver damage, 20 liver diseases without alcoholism and 50 controls. The methods included: 1) blood filtration, allowing an assessment of red blood cell deformability, plasma and whole blood viscosities, scanning electron microscopy; 2) in alcoholic group: intraerythrocyte ATP level, RBC membrane lipids analysis (cholesterol (e) and phospholipids (PL) content), search for correlations between initial blood filtration and MCV, rheological risk factors, blood filtration obtained after a fortnight’s alcohol withdrawal. In alcoholics, blood filterability was significantly decreased compared with non alcoholic liver diseases and healthy subjects. Plasma…and whole blood viscosities were raised, whereas ATP level dropped; increased cholesterol content induced a rise in C/PL ratio. These disturbances were correlated with morphological abnormalities observed with scanning electron microscopy. They were not correlated either with the severity of the liver disease (whether cirrhotic or non cirrhotic or non existent) or with macrocytosis and risk factors. They improved when patients were weaned from alcohol. Therefore red cell deformability abnormalities in alcoholics, purpose of the discussion, seem to be significant markers of alcoholism.
Keywords: Blood filterability, Plasma and blood viscosities, RBC ATP, Membrane lipids, Scanning electron microscopy, Alcoholism and liver disease
Abstract: The behaviour of haemorheological factors was studied by instrumental investigations in a group of 50 elderly subjects hospitalized for confusional states probably not secondary to an underlying organ pathology. Clinically, 19 were suffering from overall malnutrition, 30 from dehydration and one from frostbite. Substitute therapy given during hospitalization resulted in complete recovery in all patients. Although all haemorheological parameters had improved at the time of dischange, erythrocyte filtrability values never reached those of the normal control subjects. It is suggested that further studies should be carried out to establish whether there is a recognizable haemorheological pattern of aging in healthy…subjects, as well as to determine the effect that various nutrients and a state of dehydration exert on the haemorheological parameters.
Abstract: A near-zero gravity environment offers the elimination of some of the problems of handling heterogeneous systems such as blood in which the components are of disparate density and sedimentation of cells and buoyant convection occurs. Some of the physicochemical characteristics of blood are described, the basic variables measured in hemorheological studies discussed and the main effects of gravity or its absence on colloidal dispersions reviewed in relation to the effects which might be expected on the properties of blood and its constituents.