Clinical Hemorheology and Microcirculation - Volume 14, issue 2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Venous haematocrit, fibrinogen and red cell filterability were measured before and after one minute of acute hand vibration, in 8 normal subjects, 14 patients with primary Raynaud's phenomenon and 12 patients with vibration induced white finger. Acute hand vibration had no significant effect on haematocrit or fibrinogen levels. Red Cell Transit Time increased significantly in the primary Raynaud's group indicating a decrease in filterability in a large proportion of red cells. The number of clogging particles increased significantly in both the Primary Raynaud's group and the control group. Although the number of clogging particles increased in the VWF group, this…did not reach statistical significance. These results indicate that exposure to acute hand vibration causes a decrease in the filterability of red cells and this may be a contributory factor in the decrease in digital blood flow that occurs in response to acute vibration.
Keywords: Vibration, haematocrit, fibrinogen, red cell filterability
Abstract: To assess the possible influence of age, gender, cigarette smoking, menstrual cycle and oral contraceptives on red blood cell (RBC) deformability, cell transit parameters for one-hundred-ninety-four healthy adult subjects (seventy-nine males and one-hundred-fiveteen females) have been measured by filtration with the Cell Transit Analyser (CTA). The CTA provides the distribution of cell transit times of 5000 red blood cells, the mean transit time <τ> of the RBC population and different percentiles such as p50, p75, p90 and p95. First, correlations between <τ> and mean cell volume (MCV) were calculated for the entire population. Secondly, the influence of sex, age, cigarette…smoking, menstrual cycle and oral contraceptives on the RBC mean transit time was evaluated. For RBC with 80 fl < MCV < 98 fl, a very tight correlation between <τ> and MCV was found (r = 0.41; p < 0.001). No effect of age, cigarette smoking and oral contraceptives was found. Nevertheless, influence of sex and menstrual cycle were demonstrated. A significant increase of the CTA parameters measured in the female population with respect to the male population and during menstruation, preovulation and post-ovulation periods was observed. During ovulation, the CTA parameters are comparable to the same parameters in males.
Abstract: Tissue pO2 values (tibial anterior muscle), oxygen saturation, transcutaneous pO2 , arterial p02 , and rheological parameters were measured in 10 young (mean age 26,9 ± 0,9 years) as well as in 10 older (mean age 59,3 ± 5,9 years) apparently healthy volunteers during acute exposure to hypoxia according to a pressure altitude of approximately 8500 feet for 20 minutes. Hypoxia exposure was achieved by inspiration of an oxygen reduced gas mixture (116 mm Hg pO2 ). Average arterial pO2 and oxygen saturation decreased significantly in the young but not in the older volunteers. Tissue pO2 values…showed a marked and significant decrease in both groups (23.9 mm Hg to 12.8 mm Hg in the young and 20.8 mm Hg to 12.2 mm Hg in the older volunteers (medians)). Transcutaneous pO2 values also decreased significantly in both groups. The studied hemorheological parameters did not change significantly. The data show, that even a short exposure to moderately elevated pressure altitudes leads to a marked decrease in tissue oxygen tensions in young as well as in older healthy persons.
Abstract: Freshly detected diabetic (maturity-onset) cases were studied for their hemorheological parameters before starting the treatment. The parameters studied were, whole blood viscosity, plasma viscosity, red cell rigidity, red cell aggregation, hematocrit and fibrinogen. All the parameters were significantly altered. Plasma viscosity, whole blood viscosity and red cell rigidity showed increase with very high level of significance (<0.005) as compared to that of normal controls. Hematocrit was significantly increased, Rheological parameters rise even if the fasting blood sugar is around 180 mg/100 ml which is in variance with Dintenfass and Davis (1). It may be due to the absence of any…antidiabetic treatment or since the disease is recently diagnosed the correction of impaired autoregulation has yet to start in the body. Diabetes starts affecting the body as soon as it gets diagnosed or may be even before that and hemorheological changes precede the microangiopathy that appears to show the cause effect relationship between hemorheological changes and microangiopathy respectively.