Clinical Hemorheology and Microcirculation - Volume 11, issue 1-2
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Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of
Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of
Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
The following professionals and institutions will benefit most from subscribing to
Clinical Hemorheology and Microcirculation: medical practitioners in all fields including hematology, cardiology, geriatrics, angiology, surgery, obstetrics and gynecology, ophthalmology, otology, and neurology. Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit.
Important new topics will increasingly claim more pages of
Clinical Hemorheology and Microcirculation: the role of hemorheological and microcirculatory disturbances for epidemiology and prognosis, in particular regarding cardiovascular disorders, as well as its significance in the field of geriatrics. Authors and readers are invited to contact the editors for specific information or to make suggestions.
Abstract: Effect of contrast media (CM) on red blood cell (RBC) filterability was studied using a newly developed nickel mesh filtration method. The impact of CM osmolality, viscosity and iodine content on RBC filterability in this system was analyzed. Under isotonic conditions, iothalamate (48 mgI/ml, 1.3 cp) and low osmolality CM, iohexol (101 mgI/ml, 1.8 cp) did not cause any changes in RBC morphology. The RBC suspension of iothalamate was more filterable than that of iohexol because of low viscosity. However, under equal viscosity (iodine content) conditions, iothalamate caused shape change and marked decreases in RBC filterability with a small increase…in viscosity (iodine content) from 1.3 cp to 1.7 cp (48 mgI/ml to 98 mgI/ml). This change in viscosity (iodine content) corresponded to a remarkable increase in osmolality from 300 mOsm/kgH2 O to 588 mOsm/kgH2 O. Under similar conditions, iohexol did not induce any discernible shape changes and resulted in a small decrease in filterability. The present study clearly showed that the osmotic effect of CM on RBC filterability is more predominant than the effects of viscosity and iodine content.
Keywords: contrast media, red cell filterability, osmolality, viscosity, iodine, iohexol
Abstract: Fourty four patients with cholesterol levels above 250 mg/dl were randomized into two groups receiving either n-3 fatty acids (3*2 capsules daily) or placebo for 24 days. Hematocrit, blood and plasma viscosity were taken at baseline, after 12 and 24 days. The results show that blood viscosity falls in both groups. The decline is faster and stronger in the n-3 supplemented group. There is no change in plasma viscosity in either group. Hematocrit falls slightly in the n-3 group. The findings confirm earlier data but are obtained with a more rigorous study design. In conclusion we feel that n-3 fatty…acids have a strong potential for normalizing blood rheology and should be tested clinically under this aspect.
Keywords: n-3 fatty acids, fish oil, blood viscosity, diet, hemorheology
Abstract: An erythrocyte control preparation for quality assurance purposes would be of considerable value in rheological studies of erythrocyte filterability (deformability). Normal human erythrocytes stored at 4°C in citrate-phosphate-dextrose or saline-adenine-glucose-mannitol appeared to be rheologically stable for 4 weeks when tested using the Hemorheometre or Cell Transit Analyser but, after 2–3 weeks' storage, an increasing sub-population of pore clogging erythrocytes was detected by the St. George's Filtrometer. In contrast, a commercial preparation of stabilised human red blood cells (Coulter SH-RBC) was found to be more stable rheologically, as tested by all three instruments, for up to 6 weeks and thus has…potential as a rheological control preparation.
Abstract: Coronary resistances of dogs with normal coronaries were measured before and after the hematocrit values were increased by exchange transfusion of packed red blood cell suspensions. Coronary resistances increased about 9% in this group. In a second group of dogs, experiments were performed after the coronary arteries were critically stenosed. The changes in coronary resistances were more prominent in the critical stenosis group. Blood viscosity measured at a hematocrit of 45% and erythrocyte deformability indexes were also increased in the coronary sinus blood after the exchange transfusion of packed cells. These findings imply that there is a close relationship between…the rheologic properties of blood and coronary circulation. This relationship may include a positive feed-back, which will result in detrimental etTects on blood rheologic parameters.