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Cancer Biomarkers - Volume 8, issue 4-5

Purchase individual online access for 1 year to this journal.

Price: EUR 135.00
ISSN 1574-0153 (P)
ISSN 1875-8592 (E)

Impact Factor 2024: 2.2

Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion.

The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.

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Discovery and validation of ovarian cancer biomarkers utilizing high density antibody microarrays

Authors: Ramirez, Arturo B. | Lampe, Paul D.

Article Type: Research Article

Abstract: Here we demonstrate the utility of high-density antibody microarrays for ovarian cancer biomarker discovery. This report describes the technology and how it can be optimized for hypothesis-generating and testing experiments. Our previous results validated the high density antibody array technology platform, the current work expands on it utilizing a second generation array that we tested with a larger set of ovarian case and control serum samples. We then describe our strategies and methods for result validation, including Western immunoblots to confirm antibody specificity. By comparing and combining the current results with our previous study, we solidified the case that the … Show more

Keywords: Ovarian cancer, antibody microarray, biomarkers

DOI: 10.3233/CBM-2011-0215

Citation: Cancer Biomarkers, vol. 8, no. 4-5, pp. 293-307, 2011

Price: EUR 27.50
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