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Cancer Biomarkers - Volume 19, issue 4

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Price: EUR 135.00
ISSN 1574-0153 (P)
ISSN 1875-8592 (E)

Impact Factor 2024: 2.2

Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion.

The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.

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FOXF2 deficiency promotes hepatocellular carcinoma metastasis by inducing mesenchymal-epithelial transition

Authors: Dou, Chunqing | Jin, Xin | Sun, Liyuan | Zhang, Bao | Han, Mingming | Li, Tao

Article Type: Research Article

Abstract: OBJECTIVE: The transcription factor FOXF2 is reported to be down-regulated in HCC. Its deficiency is correlated with shorter disease-free survival and overall survival of HCC patients; however, the mechanism remains to be elucidated. MATERIALS AND METHODS: In this study, we performed qRT-PCR and western blotting to confirm the down-regulated FOXF2 in HCC tissue and cell lines. Then the HCC cell line Huh7 transduced with FOXF2 shRNA was adopted in a series of in vitro and in vivo assays to evaluate the cell phenotype change, migration, invasion, proliferation, colonization of circulating cell and the formation of … Show more

Keywords: Hepatocellular carcinoma (HCC), metastasis, forkhead box F2 (FOXF2), mesenchymal-epithelial transition (MET)

DOI: 10.3233/CBM-170139

Citation: Cancer Biomarkers, vol. 19, no. 4, pp. 447-454, 2017

Price: EUR 27.50

Fenofibrate protects against acute myocardial I/R injury in rat by suppressing mitochondrial apoptosis as decreasing cleaved caspase-9 activation

Authors: Zhao, Qing | Cui, Zheng | Zheng, Yan | Li, Qun | Xu, Changyuan | Sheng, Xueqi | Tao, Mei | Xu, HuiXin

Article Type: Research Article

Abstract: BACKGROUND AND AIMS: Peroxisome proliferator-activated receptor-α (PPAR-α ) activation has been reported to reduce myocardial ischemia-reperfusion (I/R) injury by inhibiting cell apoptosis. However, the antiapoptotic mechanism of PPAR-α is still unknown. Fenofibrate is a PPAR-α agonist In the present study, we investigate the effects and relevant mechanism of fenofibrate on experimental myocardial ischemia-reperfusion (I/R) injury in rats. METHODS: Adult male Wistar rats were pretreated with fenofibrate (80 mg/kg) daily for a period of 7 days. After the treatment period, myocardial I/R injury model was made … Show more

Keywords: Acute myocardial ischemia/reperfusion injury, apoptosis, PPARα, caspase-9

DOI: 10.3233/CBM-170572

Citation: Cancer Biomarkers, vol. 19, no. 4, pp. 455-463, 2017

Price: EUR 27.50

Author Index Volume 19 (2017)

Article Type: Other

Citation: Cancer Biomarkers, vol. 19, no. 4, pp. 465-470, 2017

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