Cancer Biomarkers - Volume 15, issue 6

Authors: Lian, Lian | Xia, You-You | Zhou, Chong | Shen, Xiao-Ming | Li, Xiang-Li | Han, Shu-Guang | Zheng, Yan | Mao, Zhong-Qi | Gong, Fei-Ran | Wu, Meng-Yao | Chen, Kai | Tao, Min | Li, Wei

Article Type: Research Article

Abstract: BACKGROUND: Gastric cancer is the fourth most frequent cancer and the second cause of cancer-related deaths worldwide. China has a high incidence of gastric cancer. Inflammation is a critical component of tumor progression. It has been widely accepted that gastric cancer is an inflammation-driven cancer. In this study, we investigated the application value of systemic inflammatory response (SIR) markers, platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR), in early diagnosis and prognostic prediction in patients with resectable gastric cancer. MATERIALS AND METHODS: One hundred and sixty-two patients with resectable gastric cancer were included …and separated into groups according to median pre-operative PLR or NLR values (PLR low: < 208 or PLR high: ≥ 208, and NLR low: < 4.02 or NLR high: ≥ 4.02, respectively). To evaluate the changes in PLR or NLR values after operation, we introduced the concept of postpre-operative PLR or NLR ratios (< 1 indicated PLR or NLR values were decreased after operation, while ≥ 1 suggested not decreased PLR or NLR values). RESULTS: Pre-operative PLR and NLR levels were significantly higher in gastric cancer patients compared with the healthy subjects. Low pre-operative PLR and NLR levels correlated with better clinicopathological features, including decreased depth of invasion, less lymph node metastasis and early tumor stage. Kaplan-Meier plots illustrated that higher pre-operative NLR and PLR had decreased overall survival (OS) and disease-free survival (DFS). Surgical tumor resection resulted in a significant CONCLUSIONS: PLR and NLR measurements can provide important diagnostic and prognostic results in patients with resectable gastric cancer. Show more

Keywords: Gastric cancer, platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR)

DOI: 10.3233/CBM-150534

Citation: Cancer Biomarkers, vol. 15, no. 6, pp. 899-907, 2015

Authors: Zhu, Hong | Peng, Yi-Gen | Ma, Shao-Gang | Liu, Hong

Article Type: Case Report

Abstract: BACKGROUND: The thyroperoxidase (TPO ) genetic variants in thyroid carcinoma is scarcely reported. OBJECTIVE: We report on a pedigree of thyroid papillary carcinoma and hypoechoic thyroid nodules with the TPO gene mutations. METHODS: The compound heterozygotic mutations of the TPO gene (c.2268-2269 insT and c.2090 G>A) in two patients with congenital goiters hypothyroidism were demonstrated. Fifteen family members of the proband and 105 control individuals were enrolled. The participants underwent clinical examination and molecular screening for TPO mutation. The hypoechoic thyroid nodules underwent fine needle aspiration biopsy. RESULTS: The …mutation c.2268-2269 insT was detected in the four family members with normal thyroid hormone levels. The other two members harbored the c.2090 G>A mutation. The heterozygotes had degeneratively hypoechoic thyroid nodules. The control individuals showed no mutation. The maternal grandfather developed a multifocal papillary thyroid carcinoma with lymph gland and nerve invasion in the left lobe of the thyroid gland. The maternal grandfather harbored the TPO c.2268-2269 insT mutation but without BRAF V600E mutation. Malignant cells were not observed in other members by fine needle aspiration biopsy. CONCLUSION: TPO genetic variants may be associated with thyroid carcinoma and hypoechoic thyroid nodules in a few cases. Long-term follow-up in the pedigree with congenital goiter is reasonable. Show more

Keywords: Papillary thyroid carcinoma, thyroperoxidase, mutation

DOI: 10.3233/CBM-150522

Citation: Cancer Biomarkers, vol. 15, no. 6, pp. 909-913, 2015

Article Type: Other

DOI: 10.3233/CBM-150556

Citation: Cancer Biomarkers, vol. 15, no. 6, pp. 915-920, 2015

Article Type: Other

Citation: Cancer Biomarkers, vol. 15, no. 6, pp. 921-931, 2015