Cancer Biomarkers - Volume 14, issue 6

Authors: Jia, Ming | Wang, Zhu-Jun | Li, Jing-Yuan | Yang, Shi-Long | Zhao, Hai-Zhao | Cheng, Yu-Ping | Luo, Ze-Bin | Tang, Yong-Min

Article Type: Research Article

Abstract: Background: Various studies have reported that IKZF1 deletion (IKZF1-d) is a poor prognostic factor for acute lymphoblastic leukemia (ALL) patients, however they do not agree on the level of significance for this deletion. Objective: To provide a quantitative assessment of this correlation, an updated meta-analysis of cohort studies was performed to derive a more precise estimation of the prognostic significance of IKZF1-d. Methods: Relevant studies were identified in PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang databases until January 31, 2014. A total of 15 published studies including 5021 patients were …eligible for this meta-analysis. Combined hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated with random-effects model. Results: Combined hazard ratios suggested that IKZF1 deletion (IKZF1-d) had an unfavorable impact on event-free survival (EFS) (HR=2.32, 95%CI: 1.97–2.74) and overall survival (OS) (HR=2.56, 95%CI: 1.75–3.74) in patients with ALL. The significant role of IKZF1-d in the prognosis of ALL was also observed among different subgroups stratified by statistical methodology, ethnicity, age, detection method, risk group and duration of follow up. Conclusions: The findings from this meta-analysis suggest that IKZF1 deletion can be used to serve as an independent predictive factor in patients with ALL. Show more

Keywords: Acute lymphoblastic leukemia, IKZF1, prognosis, meta-analysis

DOI: 10.3233/CBM-140425

Citation: Cancer Biomarkers, vol. 14, no. 6, pp. 493-503, 2014

Authors: Huang, Juan | Ma, Xuelei | Chen, Xiangjun | Liu, Xiaoxiao | Zhang, Binglan | Minmin, Li | Nie, Wen | Zhang, Lei | Liu, Lei

Article Type: Research Article

Abstract: Background: Many studies have shown that microvessel density (MVD) could play a potential value as prognostic biomarkers of tumors. The aim of this systematic review and meta-analysis is to evaluate the association between MVD and survival in patients with bladder cancer. Methods: Relevant literature was identified using PubMed and EMBASE. The eligible studies were assessed for quality using REMAPK (REporting recommendations for tumor MARKer prognostic studies (REMARK)). The patients’ clinical characteristics and survival outcomes in eligible studies were extracted. And then, data were synthesized to evaluate the prognostic role of the MVD in bladder cancer with hazard ratio …(HR), while the heterogeneity among studies was examined using the I2 . Results: This meta-analysis included 10 eligible studies conducted between 1998 and 2011 dealing with bladder cancer. The combined HRs and 95% confidence interval [95% CI] for disease-free survival (DFS) was 2.24 [1.20,4.17], for overall survival (OS) was 1.16 [1.02,1.33] and 1.68 [1.15,2.45] for disease-specific survival (DSS). There was evidence heterogeneity between studies, and the disease stage was a key factor for heterogeneity in subgroup analysis. Conclusions: Our studies suggested that high MVD was significantly associated with poor survival and MVD could serve as a prognostic biomarker in patients with bladder cancer. Show more

Keywords: Bladder cancer, disease-free survival(DFS), disease-specific survival(DSS), microvessel density, overall survival (OS)

DOI: 10.3233/CBM-140417

Citation: Cancer Biomarkers, vol. 14, no. 6, pp. 505-514, 2014

Article Type: Other

DOI: 10.3233/CBM-140438

Citation: Cancer Biomarkers, vol. 14, no. 6, pp. 515-517, 2014

Article Type: Other

DOI: 10.3233/CBM-2014-14614

Citation: Cancer Biomarkers, vol. 14, no. 6, pp. 519-524, 2014