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Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion.
The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.
Article Type: Research Article
Abstract: Background: Small intestinal adenocarcinoma (SIA) is often diagnosed at an advanced stage due to its rarity and nonspecific clinical manifestations. Abnormal activation of the PI3K/Akt pathway may lead to various diseases including cancer. In this study, we explored the relationship between those pathways and SIA. Objective: To investigate the expression of PI3K, phospho-Akt (p-Akt) and PTEN in SIA to evaluate their clinical significance. Methods: Expression of PI3K, p-Akt and PTEN biomarkers were examined by quantum dots-based immunofluorescence histochemistry (QDs-IHC) and traditional immunohistochemistry (IHC). There are 53 SIA samples, 11 non-cancer tissue samples and 11 normal small …intestine tissues. Results: The positive frequencies of PI3K and p-Akt expression were significantly higher in the SIA group (77.4%, 41/53 and 77.4%, 41/53, respectively) than that in the non-cancer group (36.4%, 4/11 and 27.3, 3/11, respectively) and normal small intestine tissue group (36.4%, 4/11 and 18.2, 2/11, respectively). However, the difference of the positive rates of PTEN expression in three groups did not reach a statistical difference (P=0.761). The IHC results were in concordance with the QDs-IHC. Conclusions: These observations support that PI3K/Akt pathway is highly activated in SIA, which may implicate therapeutic targeting of the PI3K/Akt signaling pathway for its treatment. Show more
Keywords: Adenocarcinoma, PI3K, PTEN, p-Akt, quantum dots, small intestine
Citation: Cancer Biomarkers, vol. 13, no. 4, pp. 299-305, 2013
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