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This journal will publish review articles and original research that deal with a novel and very important area of biology. The ultimate objective is to understand the integrative regulation of higher organisms in their entire complexity. It has been firmly established already that the Nervous, Endocrine and Immune systems form a regulatory network, a Super-System, which governs all events from conception till death in higher animals and in man, including physiological and pathophysiological processes.
It follows from the above definition that a review journal covering this area of Biomedicine must operate in a “multidisciplinary” fashion. The rapidly accumulating and fragmented information available today will be collected, organized and interpreted; the elements, compounds, cells and tissues will be fitted into living organisms and our knowledge of the biology of such higher organisms will be enhanced. The rules of physiological interactions during homeostasis must be understood and also the regulatory interactions in diseases must be followed, which operate during pathophysiological conditions (allostasis).