Affiliations: [a] Department of Ultrasound, Peking University, First Hospital, Beijing, China | [b] Department of Pathology, Peking University, First Hospital, Beijing, China | [c] Breast Disease Center, Peking University, First Hospital, Beijing, China | [d] Department of Interventional Radiology and Vascular Surgery, Peking University, First Hospital, Beijing, China
Correspondence:
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Corresponding author: Yinghua Zou, Department of Interventional Radiology and Vascular Surgery, Peking University, First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. Tel.: +86 10 8357 2633, +86 10 13801105222; E-mail: [email protected].
Abstract: BACKGROUND: Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%) in the global cancer statistics 2020. OBJECTIVE: To evaluate the diagnostic value of ultrasound elastography combined with multi-parameters in differentiating category 4 benign and malignant lesions in the breast imaging reporting and data system (BI-RADS). METHODS: This study retrospectively analyzed 206 patients (213 breast lesions) who visited the Department of Breast Surgery and underwent a breast core needle biopsy in the Department of Ultrasound in Peking University First hospital from April to December 2019. The shear wave velocity (SWV) values were collected at the following locations by virtual touch tissue imaging quantification (VTIQ): breast lesion interior, breast lesion margin, surrounding glands, and surrounding fat. Simultaneously, the strain ratio (SR) of breast lesions to glands and the area ratio (AR) of breast lesions were collected under strain elastography and a two-dimensional ultrasound mode. RESULTS: Univariate analysis found that the SWV value, measured by ultrasound elastography parameters, and the AR between the elasticity and the two-dimensional ultrasound breast lesions showed statistical differences when differentiating benign and malignant lesions (p< 0.05). Binary logistic regression analysis found that the SWV values of the lesion interior and the surrounding glands were statistically significant. The joint predictors were calculated and analyzed by Receiver Operating Characteristic (ROC), and it was found that the joint predictors and the SWV values of the lesion interior have great diagnostic value. The cut-off value, sensitivity and specificity of the joint predictor and the SWV value of the lesion interior were > 3.65, 88.35% and 76.36% and > 5.55 m/s, 79.61% and 82.73%, respectively. CONCLUSIONS: Ultrasound elastography combined with multi-parameters has good diagnostic value in differentiating BI-RADS 4 breast lesions.
Keywords: Ultrasound elastography, strain elastography, ARFI, VTIQ, SWV, breast lesion
