The antithrombotic effect of some EUROBIOMAT project test polymers in vivo

Article type: Research Article

Authors: Mhic Iomhair, Maura^{; *} | Lavelle, S.M.

Affiliations: Department of Experimental Medicine, Clinical Science Institute, University College, Galway, Ireland

Correspondence: [*] Corresponding author: Department of Experimental Medicine, Clinical Science Institute, University College Galway, Ireland. Tel.: +353 91525 046; Fax: +353 91526 505.

Abstract: The antithrombotic effect of six polymers was tested by weighing the amount of thrombus formed on polymer catheters of diameters 1.45–1.7 mm inserted in rat vein for one hour, and compared to that of platinum of diameter 0.5 mm. Ten observations were made of each polymer. The order of decreasing biocompatibility in μg thrombus/sq mm surface was polyetherurethane (14.6), polypropolene (17.9), polyvinylcloride DEHP (23.5), polyethylene (27.3), polyvinylchloride TOTM (37.8) and polymethylsiloxane (39.1). Deposit on platinum was 200 μg/sq mm. These levels correspond to those attained by 150âĂŞ333 iu heparin given intravenously, or warfarin from just inside the non-haemorrhagic (15% factor II) to the high-risk haemorrhagic range (8% factor II). Current polymer surfaces may exceed the antithrombotic biocompatibility afforded by drugs to platinum surface.

Keywords: Polymer, biomaterials, implantation, vein, thrombogenicity, rat

DOI: 10.3233/THC-1996-4402

Journal: Technology and Health Care, vol. 4, no. 4, pp. 385-388, 1996