Abstract: BACKGROUND:The analysis of seismic stability of structure is important in the field of engineering. OBJECTIVE:This study aims to verify the reliability of numerical simulation in seismic stability of reinforced concrete (RC) frame structure. METHODS:Based on the numerical simulation, the material constitutive model of RC frame structure was introduced and then a finite element model was established through ABAQUS to analyze its seismic stability. RESULTS:The simulation results of ABAQUS were similar to the test values, the tangent slope of the skeleton curve of the structure decreased gradually, the interstorey displacement of storey 1 was the largest, the maximum error of the interstorey displacement angle was 0.005, and the ductility coefficient was 4. CONCLUSIONS:The experimental results verify the reliability of the numerical simulation method and provide some theoretical support for its better application in the study of seismic stability.