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Applying linked data approaches to pharmacology: Architectural decisions and implementation

Issue title: Linked Data for Health Care and the Life Sciences

Article type: Research Article

Authors: Gray, Alasdair J.G.; | Groth, Paul | Loizou, Antonis | Askjaer, Sune | Brenninkmeijer, Christian | Burger, Kees | Chichester, Christine | Evelo, Chris T. | Goble, Carole | Harland, Lee | Pettifer, Steve | Thompson, Mark | Waagmeester, Andra | Williams, Antony J.

Affiliations: University of Manchester, UK | VU University Amsterdam, The Netherlands | H. Lundbeck A/S, Denmark | Netherlands Bioinformatics Center, The Netherlands | Maastricht University, The Netherlands | Connected Discovery, UK | Royal Society of Chemistry, UK

Note: [] Corresponding author. E-mail: [email protected].

Keywords: pharmacology, linked data, data integration

DOI: 10.3233/SW-2012-0088

Journal: Semantic Web, vol. 5, no. 2, pp. 101-113, 2014

Published: 2014
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Abstract

The discovery of new medicines requires pharmacologists to interact with a number of information sources ranging from tabular data to scientific papers, and other specialized formats. In this application report, we describe a linked data platform for integrating multiple pharmacology datasets that form the basis for several drug discovery applications. The functionality offered by the platform has been drawn from a collection of prioritised drug discovery business questions created as part of the Open PHACTS project, a collaboration of research institutions and major pharmaceutical companies. We describe the architecture of the platform focusing on seven design decisions that drove its development with the aim of informing others developing similar software in this or other domains. The utility of the platform is demonstrated by the variety of drug discovery applications being built to access the integrated data.

An alpha version of the OPS platform is currently available to the Open PHACTS consortium and a first public release will be made in late 2012, see http://www.openphacts.org/ for details.

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