rTMS with motor training modulates cortico-basal ganglia-thalamocortical circuits in stroke patients

Article type: Research Article

Authors: Chang, Won Hyuk | Kim, Yun-Hee | Yoo, Woo-Kyoung | Goo, Kyoung-Hyup | Park, Chang-hyun | Kim, Sung Tae | Pascual-Leone, Alvaro

Affiliations: Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea | Department of Physical and Rehabilitation Medicine, Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea | Department of Physical and Rehabilitation Medicine, Hallym University Sacred Heart Hospital, Dongan-ku, Anyang, Republic of Korea | Department of Physical and Rehabilitation Medicine, Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea | Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea | Department of Diagnostic Radiology and Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Republic of Korea | Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Kirstein Building, Boston, MA, USA

Note: [] Corresponding author: Yun-Hee Kim, MD, PhD, Professor, Department of Physical and Rehabilitation Medicine, Stroke and Cerebrovascular Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea. Tel.: +82 2 3410 2824, 2818; Fax: +82 2 3410 0052; E-mails: [email protected]; [email protected]

Abstract: Background and purpose: Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled with motor training in patients with hemiparesis after stroke. Methods: Twenty-one patients were randomly divided into two groups, and received either real or sham rTMS. Ten daily sessions of 1,000 pulses of real or sham rTMS were applied at 10 Hz over the primary motor cortex of the affected hemisphere, coupled with sequential finger motor training of the paretic hand. Functional MRIs were obtained before and after training using sequential finger motor tasks, and performances were assessed. Results: Following rTMS intervention, movement accuracy of sequential finger motor tasks showed significantly greater improvement in the real group than in the sham group (p < 0.05). Real rTMS modulated areas of brain activation during performance of motor tasks with a significant interaction effect in the sensorimotor cortex, thalamus, and caudate nucleus. Patients in the real rTMS group also showed significantly enhanced activation in the affected hemisphere compared to the sham rTMS group. Conclusion: According to these results, a 10 day course of high-frequency rTMS coupled with motor training improved motor performance through modulation of activities in the cortico-basal ganglia-thalamocortical circuits.

Keywords: Stroke, repetitive transcranial magnetic stimulation, functional MRI, motor function, cortico-basal ganglia-thalamocortical circuits

DOI: 10.3233/RNN-2012-110162

Journal: Restorative Neurology and Neuroscience, vol. 30, no. 3, pp. 179-189, 2012