Reduced body cell mass in type 2 diabetes mellitus: reversal with a diabetes-specific nutritional formula

Article type: Research Article

Authors: Tatti, Patrizio^a | di Mauro, Patrizia^a | Neri, Marisa^a | Pipicelli, Giuseppe^b | Strollo, Felice^c

Affiliations: [a] UOCA di Endocrinologia e Diabetologia, ASL RMH, via XXIV Maggio, Marino, 00047 Rome, Italy. e-mail: [email protected]; [email protected] | [b] UOC Diabetologia e Dietologia, ASP Catanzaro, Catanzaro, Italy | [c] UOC di Endocrinologia, INRCA, Rome, Italy

Abstract: Subjects with type 2 diabetes are in a continuous catabolic state due to increased neoglycogensis during most of the fasting and the postprandial period. We compared the body cell mass index (BCMI) of 257 subjects with type 2 diabetes mellitus (T2DM) and 216 non-diabetic controls and found a statistically significant lower value in the diabetic subjects. This abnormality was reversed after 6 months of treatment with a diabetes-specific nutritional formula. Furthermore, in a population of 715 diabetic subjects without other diseases, we found that the BCMI was inversely correlated with the prevailing HbA1c and the duration of the disease.

Keywords: T2DM, Nutrition, Body cell mass

DOI: 10.3233/s12349-010-0004-0

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 3, no. 2, pp. 133-136, 2010