Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Naghizadeh, Mehrdada | Karajibani, Mansourb; * | Fanaei, Hamedc; * | Montazerifar, Farzanehb; d; e | Dashipour, Alirezae
Affiliations: [a] Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [b] Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [c] Pregnancy Health Research Center, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [d] Pregnancy Health Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran | [e] Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Department of Food Science, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Correspondence: [*] Corresponding authors. Hamed Fanaei, PhD, Pregnancy Health Research Center, Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Tel.: +98 54 33295717 20; Fax: +98 54 33295728; Postal code: 9816743181; E-mail: [email protected] and Mansour Karajibani, PhD, Associate professor, Health Promotion Research Center, Nutrition Department, Medical School, Zahedan University of Medical Sciences, Zahedan, Iran. Tel.: +98 54 33295717 20; Fax: +98 54 33295728; Postal code: 9816743181; E-mail: [email protected].
Abstract: Synbiotic supplementation can improve metabolic disorders. The aim of this study was to assess the impact of synbiotic supplementation on the levels of asprosin, lipid profile, glucose, and insulin resistance in pregnant rats fed a high-fat diet (HFD). Rats were divided into three groups: control group (fed base chow), HFD group, and HFD + synbiotic group. Levels of blood glucose, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), insulin, and asprosin levels were measured. Birth weight of offspring in the HFD + synbiotic group was significantly lower than in the HFD group. Similarly, serum asprosin, insulin, insulin resistance, TG and total cholesterol levels in the HFD + symbiotic group were significantly lower than in the HFD group. Asprosin levels had a significant and positive correlation between food intake in the first ten days of the experiment and gestation period, fasting blood sugar (FBS), TG, and homeostatic model assessment (HOMA) index. Moreover, asprosin levels had a significant and negative correlation with HDL and insulin levels. Results showed, synbiotic supplementation has beneficial effects on obese animals and improves weight gain during pregnancy, pup birth weight, FBS, insulin resistance and lipid profile. These advantages of synbiotic supplementation could be mediated by reducing serum asprosin levels.
Keywords: Asprosin, symbiotic, metabolic syndrome, pregnancy, high-fat diet
DOI: 10.3233/MNM-210595
Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 15, no. 1, pp. 81-90, 2022
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]