Effects of conjugated linoleic acid supplementation on serum leptin levels, oxidative stress factors and tumor marker in rectal cancer patients undergoing preoperative chemoradiotherapy

Article type: Research Article

Authors: Faramarzi, Elnaz^a | Mohammadzadeh, Mohammad^b | Sanaie, Sarvin^c | Andersen, Vibeke^d | Mahdavi, Reza^{e; *}

Affiliations: [a] Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | [b] Department of Radiotherapy, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran | [c] Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran | [d] Organ Center, Hospital of Southern Jutland, Aabenraa, Denmark | [e] Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Correspondence: [*] Corresponding author: Reza Mahdavi, Drug applied Research center, Tabriz University of Medical Sciences, Daneshghah street, Tabriz, postal code 5167994434, Iran. Tel.: +98 9141130310; Fax: +98 4133369315; E-mail: [email protected].

Abstract: BACKGROUND:Inflammation is considered as one of the major factors in chemoradiotherapy toxicity. It has been reported that conjugated linoleic acid (CLA) has anti-inflammatory properties. OBJECTIVE:The aim of this study was to assess the effect of CLA supplementation on serum levels of leptin, interleukin 8 (IL-8), malondialdehyde (MDA), total antioxidant status (TAS), and carcinoembryonic antigen (CEA) in rectal cancer patients treated with chemoradiotherapy. METHODS:In this study, 34 rectal cancer patients were allocated to either the CLA group, who received four 1000 mg capsules (each capsule containing 760 mg CLA; 4 capsules providing 3 g CLA) 3 times/day, or the placebo group, who received 4 placebo capsules 3 times/day, for 6 weeks. RESULTS:The mean serum leptin level insignificantly increased in both groups; however, this elevation was remarkable in the CLA group. CLA supplementation reduced IL-8 by –0.62 pg/mL while placebo supplementation decreased it by –0.44 pg/mL. CEA levels were decreased by CLA supplementation, while its reduction in the placebo group was negligible compared to the CLA group. The elevation of MDA levels after CLA supplementation was about half of the placebo group in the CLA group. CONCLUSION:Since this study was the first to assess the effect of CLA supplementation on a small number of cancer patients, it is suggested further studies are conducted on larger sample size with various doses of CLA to obtain more clear results.

Keywords: Rectal cancer patients, preoperative chemoradiotherapy, conjugated linoleic acid, oxidative stress, leptin

DOI: 10.3233/MNM-200507

Journal: Mediterranean Journal of Nutrition and Metabolism, vol. 14, no. 3, pp. 245-253, 2021