Affiliations: [a] Department of Preclinical Sciences “LITA Vialba”, Faculty of Medicine, University of Milan, Via G.B. Grassi 74, 20157 Milan, Italy. e-mail: [email protected]
| [b] Department of Applied Health Sciences, Section of Human Nutrition and Dietetics, Faculty of Medicine, Endocrinology and Nutrition Unit, ASP, II. AA.RR, University of Pavia, 27100 Pavia, Italy | [c] Laboratory of Biochemical Chemistry, Neurological Institute “C. Mondino”, I.R.C.C.S., University of Pavia, 27100 Pavia, Italy
Abstract: Objective: To determine the oxidative balance and plasma fatty acid composition of overweight and obese women. Design: Comparative, descriptive study on 60 overweight or obese (BMI 25–33 kg/m2), normotensive, nondiabetic women and 60 age-matched lean healthy women (BMI < 25 kg/m2). Measurements: Plasma lipid, hydroperoxide, and antioxidants levels, fatty acid composition and the susceptibility of lipoproteins to peroxidation. Results: Compared to the lean control group, the patient group had higher susceptibility of lipoproteins to peroxidation and higher peroxide levels. In contrast, the polyunsaturated fatty acids, in particular the ω-3 species, and the antioxidants were lower in the patient group. Conclusions: The present study shows that overweight and obese people have oxidative balance impairment. The higher susceptibility of lipoproteins to peroxidation is the probable molecular mechanism that promotes a reduction in high unsaturated (and in particular ω-3) fatty acids, as well as antioxidants in the plasma of the overweight and obese subjects.
Keywords: Over weight, Obesity, Oxidative stress, Lipid peroxidation