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Hepatoprotective effect of aqueous and pure extracts of raisin in alloxan-induced diabetic rats


The present study was conducted to evaluate the possible antioxidant effects of raisin aqueous and pur extract of “Karkni” on liver histology, antioxidant enzymes activities and lipid peroxide levels in liver of diabetic and normal rats. 125 mg/kg of pure and aqueous extract of “Karkni” were orally administered daily to alloxan-diabetic rats for 4 weeks. Alloxan- induced diabetic rats showed significant increases in the levels of total protein and malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT) and reduced glutathione (GSH) levels were significantly decreased compared to normal rats (p < 0.05). Also, no significant effects on glutathione peroxidase (GPx) activity in diabetic rats were observed. The changes of the above parameters to their normal levels after 4 weeks of treatment were observed mainly with the pure extract. The results suggesting that pure extract suppresses the liver tissue inflammation attenuate lipid peroxidation and can be helpful in reducing liver damage caused by alloxan-induced diabetes.