Synthesis and characterization of chemosensor: Investigation of cyanide sensing and study as live cell imaging

Article type: Research Article

Authors: Arun, Shiva | Tripathi, Amit Kumar | Singh, Puspendra^{; *}

Affiliations: Department of Chemistry, Dr. Shakuntala Misra National Rehabilitation University, Lucknow, India

Correspondence: [*] Corresponding author: Puspendra Singh, Department of Chemistry, Dr. Shakuntala Misra National Rehabilitation University, Lucknow –226017, India. Email: [email protected].

Abstract:  Chemosensor A, (E)-(4-(2-((2-hydroxynaphthalene-1-yl)methylene)hydrazinyl)benzonitrile has been synthesized by condensation of 4-cyanophenylhydrazine hydrochloride with 2-hydroxy-1-naphthaldehyde in ethanol solvent at ∼80°C. The chemosensor A, has been characterized by FT-IR, ESI-MS and 1H-NMR spectroscopic techniques. The chemosensor A has been investigated for selective cyanide ion sensing ability through UV–visible and fluorescence spectra. Further the chemosensor A was also employed as live cell imaging reagent for intra-cellular detection of cyanide ion in SW480 cells.

Keywords: Cyanide, chemosensor, fluorescence spectra, bio-imaging, SW480 cells

DOI: 10.3233/MGC-240001

Journal: Main Group Chemistry, vol. 23, no. 2, pp. 157-163, 2024