Tri-butyltin(IV)phenoxyacetohydroxamate: Synthesis, characterization, biological evaluation and molecular docking studies

Article type: Research Article

Authors: Sharma, Vandna^{; *} | Choudhary, Vineet Kumar

Affiliations: Department of Chemistry, IEC University Baddi, Solan, Himachal Pradesh, India

Correspondence: [*] Corresponding author: Department of Chemistry, IEC University Baddi, Solan, 174103, Himachal Pradesh, India. Mob. No.: +91 9459002407; E-mail: [email protected].

Abstract: The tri-organotin(IV) complex of composition [n-Bu3Sn(C6H5OCH2CONHO)] has been synthesized by using Bu3SnCl and potassium phenoxyacetohydroxamate ligand (KPAH) in pre-determined molar ratio of methanol and tetrahydrofuran. These are characterized by spectral techniques like FTIR, 1 H NMR and mass spectrometry. Studies on electrochemical processes are carried out using cyclic voltammetry. The in vitro antibacterial and antifungal activities performed by using minimum inhibitory concentration (MIC) method has revealed complex as biologically active. Molecular docking of the ligand and complex has been performed against the fungal receptor (PDB ID: 1UKC) to study the interactions between compound and receptor.

Keywords: Tri-butyltin(IV)phenoxyacetohydroxamate complex, spectral studies, antimicrobial activity, molecular docking

DOI: 10.3233/MGC-230008

Journal: Main Group Chemistry, vol. 23, no. 1, pp. 103-111, 2024