Affiliations: [a]
School of Material Chemistry, Japan Advanced Institute of Science and Technology (JAIST), 1-1 Asahidai, Nomi city, Ishikawa, Japan
| [b]
Department of Chemistry, Maitreyi College, University of Delhi, Chanakyapuri, New Delhi, India
| [c]
Department of Chemistry, Atma Ram Sanatan Dharma College, University of Delhi, Dhaula Kuan, New Delhi, India
| [d]
Department of Chemistry, University of Delhi, Delhi, India
Correspondence:
[*]
Correspondence to: Rajeev Singh, Department of Chemistry, Atma Ram Sanatan Dharma College, University of Delhi, Dhaula Kuan, New Delhi-110007, India. Tel.: +91 9311 2255 01; Fax: +91 1124111390; E-mail: [email protected].
Abstract: A group of organotin(IV) complexes with thiohydrazones derived from phenethylamine were synthesised in 1:1 complexes. The following organotin(IV) complexes have been synthesized: (C6H5CH2)2Sn(L1)Cl2, (p-ClC6H4CH2)2 Sn(L2)Cl2, (C6H5CH2)2Sn(L2)Cl2, (C6H5CH2)2Sn(L3)Cl2, (p-ClC6H4CH2)2Sn(L3)Cl2, (C6H5CH2)2Sn(L4)Cl2, (C6H5CH2)3 Sn(L5)Cl, where L1 = benzaldehyde phenylethylamine N-thiohydrazone, L2 = salicylaldehyde phenylethylamine N-thiohydrazone, L3 = p-methylacetophenone phenylethylamine N-thiohydrazone, L4 = cinnamaldehyde phenylethylamine N-thiohydrazone and L5 = benzaldehyde 2-phenylethyl N-(2-phenylethyl-N-thio)-1,2-ethanediamine. The complexes were pure and characterized by elemental analysis and molecular weight determination studies. Infrared and multinuclear (1H, 13C, 119Sn NMR) spectra of the compounds are compatible with the presence of a neutral ligand attached to the metal through the S-C-N-N chelating system and formation of hexacoordinated tin complexes. Biological screenings for anti-tuberculosis, anti-fertility, anti-fungal (ED50) and anti-bacterial activity were performed. Using thermogravimetric (TGA) and differential thermal analysis (DTA) various thermodynamic and kinetic parameters were calculated including reaction order (n), apparent activation energy (Ea), apparent activation entropy (S#) and heat of reaction (ΔH) and correlated with the structural aspects for solid-state decomposition of complexes.
