Affiliations: [a] Biology Department, Faculty of Science for Girls, King Abdulaziz University, Saudi Arabia | [b] Biology Department, Faculty of Science and Arts-Khulais, University of Jeddah, Saudi Arabia
Correspondence:
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Corresponding author: Ahmed Megahed Abouwarda, Biology Department, Faculty of Science and Arts-Khulais, University of Jeddah, Saudi Arabia. Tel.: +966560011481; E-mail: [email protected]
Abstract: Staphylococcus aureus is a human pathogen that causes a wide range of infections worldwide. In this study, 40 clinical isolates of S. aureus were tested for their susceptibility to oxacillin and to different classes of antibiotics by disc diffusion method. Data revealed that out of these 40 isolates, 28 were MRSA. Most isolates were not only resistant to oxacillin but also found resistant to a number of other antibiotics. Propolis is a mixture of beeswax and resins collected by the honeybee from plant buds, leaves, and exudates. It has been used for centuries in folk medicine. The antimicrobial activity of ethanolic extract of propolis alone or in combination with antimicrobial drugs against MRSA isolates was evaluated. The results showed that the propolis extract was found to exhibit antimicrobial activity against all tested isolates. Also the results demonstrated the combination between propolis and some tested antimicrobial drugs in vitro is effective against multi-drug resistance MRSA.
