Affiliations: [a] Department of Laboratory, The Third People’s Hospital of Linyi, Linyi, Shandong, China
| [b] Department of Oncology, The Third People’s Hospital of Linyi, Linyi, Shandong, China
| [c] Department of General Surgery, Linyi Cancer Hospital, Linyi, Shandong, China
Corresponding author: Qing-Pin Tai, Department of General Surgery, Linyi Cancer Hospital,
Linyi, Shandong, China. E-mail: [email protected].
Abstract: The synthesis and characterization of six novel naphthol derivatives (1–6) were realized by means of IR, 1H NMR, HRMS and single crystal X-ray crystallography. The anticancer activities of these compounds were investigated against three human gastric cancer cells (MGC-803, SGC-790, MKN45) by MTT assay. In addition, the relationship between anticancer activity and structure of compounds (1–3) was further investigated through molecular docking study.
Keywords: Naphthol, X-ray, cancer cell, molecular docking