Anticancer agents from plants

Article type: Research Article

Authors: Morsy, Nagy^{a; b; *}

Affiliations: [a] Department of Chemistry, Faculty of Sciences and Arts, Khulais, University of Jeddah, Jeddah, Saudi Arabia | [b] Department of Chemistry of Natural Compounds, National Research Centre, Dokki, Cairo, Egypt

Correspondence: [*] Corresponding author: Nagy Morsy. E-mail: [email protected].

Abstract:  Natural products remain an important source of new drugs. Many natural materials are used for treatment of diseases. The diversity in natural compounds make it a rich source for discovering and studying the biological activities for overcoming of several diseases. Cancer is a leading reason of death all over the world. Many anticancer agents originate from plant sources occupies an important position in anticancer studies. The advances happened in chemical and clinical tools encourage many of researcher to rediscover many natural compounds and plants could not be studied in past. This chapter reviews the natural products from plant sources with anticancer activity. It represents the most effective natural products with anticancer activity. Their structures and chemical classifications with the plant sources are presented. The article focuses on the promising natural products and the ongoing trails to evaluate the plant wealth as anticancer phytochemicals. The natural compounds in the advanced stages of clinical development is discussed.

Keywords: Phytochemical studies, natural products, anticancer agents, drug discovery, clinical developments

DOI: 10.3233/MGC-180689

Journal: Main Group Chemistry, vol. 18, no. 3, pp. 169-191, 2019