Novel pyran derivatives: Synthesis and anticancer activity in the bones

Article type: Research Article

Authors: Gale, Tumenjiri^{a; 1} | Zhang, Zhifang^{b; c; 1} | Liu, Yang^{b; *} | Pan, Lei^{b; *}

Affiliations: [a] Inner Mongolia University For The Nationalities, Tongliao, Inner Mongolia, China | [b] Department of Orthopedics, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, China | [c] Tong Liao City Hospital, Tongliao, Inner Mongolia, China

Correspondence: [*] Corresponding author: Yang Liu and Lei Pan, Department of Orthopedics, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, China. E-mails: [email protected] and [email protected]. (Lei Pan).

Note: [1] These authors contributed equally to this work.

Abstract: The reaction of 3,5-cyclohexanedione (or 4-hydroxy-6-methyl-pyran-2-one) with aromatic aldehyde and malononitrile gave two kinds of pyran derivatives (1–8) and their structures were characterized via IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The in vitro anticancer activity of the synthesized products was studied and evaluated, in which four human bone cancer cells (MG63, U2OS, 143B and HOS) were used in the screening tests. The results showed that compared with compounds 5–8, compounds 1–4 with ketone ring exerted rather potent activity.

Keywords: 3, 5-cyclohexanedione, X-ray, cancer cell

DOI: 10.3233/MGC-180681

Journal: Main Group Chemistry, vol. 17, no. 4, pp. 317-323, 2018