A new Pb(II)-based coordination polymer constructed by 5-((4-carboxyphenoxy) methyl)benzene-1,3-dioic acid and N-donor co-ligand: Crystal structure and anti-lymph cancer activity

Article type: Research Article

Authors: Fan, Rong^a | Sun, Suqin^b | Yang, Shanjun^c | Liu, Li^d | Ma, Guoqing^a | Tang, Qiang^{e; *}

Affiliations: [a] Department of Endocrinology and Geriatric, The Second Hospital Affiliated Heilongjiang University of Chinese Medicine, Harbin, China | [b] Department of Oncology and Hematology, The Second Hospital Affiliated Heilongjiang University of Chinese Medicine, Harbin, China | [c] Department of Pneumology, The Second Hospital Affiliated Heilongjiang University of Chinese Medicine, Harbin, China | [d] Department of Cardiology, The First Hospital Affiliated Heilongjiang University of Chinese Medicine, Harbin, China | [e] Department of Rehabilitation, The Second Hospital Affiliated Heilongjiang University of Chinese Medicine, Harbin, China

Correspondence: [*] Corresponding author: Qiang Tang, Department of Rehabilitation, The Second Hospital Affiliated Heilongjiang University of Chinese Medicine, Harbin 150080, China. E-mail: [email protected].

Abstract: A new Pb(II)–based coordination polymer with the chemical formula of [Pb(HL)(phen-dione)](H2O)2 (1) has been successfully prepared under hydrothermal conditions through using organic carboxylic acid ligand 5-((4-carboxyphenoxy)methyl)benzene-1,3-dioic acid (H3L) and N-donor chelating ligand 1,10-phenanthroline-5,6-dione (phen-dione). The as-prepared complex has been characterized by single-crystal X-ray structural analysis, Powder X-ray diffraction (PXRD) and elemental analyses, which reveals that the title complex 1 crystallized in triclinic crystal system (Z = 2) with space groups of P-1 and reveals a 1D chain-like structure that is further extended to the 3D supermolecular network though π–π and H-bond interactions. Complex 1 was transformed to the nanoscale regime (ca. 190 nm) by mechanical grinding to yield the nano-1, maintaining its structure and crystallinity. Furthermore, the anti-lymph cancer activity of the nano-1 has been evaluated via the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.

Keywords: Coordination polymer, X-ray diffraction, nanoscale regime, MTT assay

DOI: 10.3233/MGC-180679

Journal: Main Group Chemistry, vol. 17, no. 4, pp. 309-315, 2018