Novel 4-hydroxycoumarin derivatives: Inhibiting growth of human lung cancer cells

Article type: Research Article

Authors: Chen, Lan-Tao | Zhu, Kai-Bin | Qu, Chang-Fa^{; *}

Affiliations: Department of Thoracic Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China

Correspondence: [*] Corresponding author: Chang-Fa Qu, Department of Thoracic Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150080, China. E-mail: [email protected].

Abstract: The reaction of 4-hydroxycoumarin with aromatic aldehyde and malononitrile (or ethyl cyanoacetate) gave two kinds of 4-hydroxycoumarin derivatives (1–6) and their structures were characterized via IR, 1H NMR, HRMS, and single crystal X-ray crystallography. The in vitro anticancer activity of the synthesized products was studied and evaluated, in which four human lung cancer cells (A549, NCI-H1299, H1650 and PC9) were used in the screening tests. The results showed that compared with compounds 1–3, compounds 4–6 with ethyl ester group exerted rather potent activity.

Keywords: 4-Hydroxycoumarin, X-ray, lung cancer cells

DOI: 10.3233/MGC-180677

Journal: Main Group Chemistry, vol. 17, no. 4, pp. 301-307, 2018