Metal complexes of hydrazones and their biological, analytical and catalytic applications: A review

Article type: Research Article

Authors: Shakdofa, Mohamad M.E.^; | Shtaiwi, Majed H. | Morsy, Nagy^; | Abdel-rassel, Tayseer M.A.^;

Affiliations: Chemistry Department, Faculty of Sciences and Arts, Khulais, King Abdulaziz University, Saudi Arabia | Inorganic Chemistry Department, National Research Center, Dokki, Cairo, Egypt | Chemistry of Natural Compounds, National Research Center, Dokki, Cairo, Egypt | Biology Department, Faculty of Sciences and Arts, Khulais, King Abdulaziz University, Saudi Arabia | Botany Department, Faculty of Science, Suez canal University, Egypt

Note: [] Corresponding author: Mohamad M.E. Shakdofa, E-mail: [email protected]

Abstract: This is the first comprehensive review of the biological activity of hydrazone-transition metal complexes. Hydrazone complexes gained much attention because of their antifugial, antibacterial anticonvulsant, and analgesic, antiinflammatory, antimalarial, antimicrobial, antituberculosis, anticancer, and antiviral activities. Additionally, some of the hydrazone complexes were used in treatment of iron overload diseases. One application, which reflects the importance of hydrazone complexes, is their use in detection and determination of metals and some organic constituents in pharmaceutical formulations. This review will provide an overview of the biological, analytical and catalytic applications of this category of complexes.

Keywords: Hydrazones, Transition metal complexes, biological, analytical, catalytic application

DOI: 10.3233/MGC-140133

Journal: Main Group Chemistry, vol. 13, no. 3, pp. 187-218, 2014