Affiliations: Department of Chemistry, Seethalakshmi Ramaswami College, Tiruchirappalli, Tamil Nadu, India
Note:  Corresponding author: V. Gomathi, Department of Chemistry, Seethalakshmi Ramaswami College, Tiruchirappalli 620 002, Tamil Nadu, India. E-mails: [email protected], [email protected]
Abstract: Novel coordination complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 4-(3-ethoxy-2-hydroxybenzylideneamino)-N-(pyridin-2-yl)benzenesulfonamide (ESSP) Schiff base derived from sulfapyridine and 3-ethoxysalicylaldehyde. The nature of bonding and the structural features of the Schiff base and its complexes have been deduced from elemental analysis, molar conductance, magnetic susceptibility measurements, IR, 1H NMR,13C NMR, UV-Vis, cyclic voltammetry, fluorescence and EPR spectral studies. The spectral data of the complexes have revealed bidentate coordinating nature of the Schiff base through azomethine nitrogen atom and phenolic oxygen. The Schiff base and its metal complexes were screened for their antimicrobial activity. The complexes showed enhanced antimicrobial activity as compared to uncomplexed Schiff base.
Keywords: Sulfa drug, Schiff base, metal complexes, antibacterial, antifungal