Article type: Research Article
Authors: Shakdofa, Mohamad M.E.; | EL-Saied, Fathy A.; | Al-Hakimi, Ahmed N.
Affiliations: Faculty of Science and Arts, Department of Chemistry, Khulais, King Abdulaziz University, King Abdulaziz, Saudi Arabia | National Research Centre, Inorganic Chemistry Department, Dokki, Cairo, Egypt | Faculty of Science, Department of Chemistry, El-Menoufia University, Shebin El-Kom, Egypt | Faculty of Science, Department of Chemistry, Qassim University, Qassim, Saudi Arabia (KSA) | Faculty of Science, Department of Chemistry, Ibb University, Ibb, Yemen
Note: [] Corresponding author: Ahmed N. Al-Hakimi, Faculty of Science, Department of Chemistry, Ibb University, P.O. 70270, Ibb, Yemen. E-mail: [email protected]
Abstract: Ti(IV), VO(II), Ni(II), Co(II), Mn(II), Cu(II), Zn(II), Cd(II), Sn(II), ZrO(II), UO2(II) Fe(III), Ru(III), Ho(III) and Yb(III) complexes of 2-(p-toluidino)-N′-(2-hydroxbenzylidene) acetohydrazide have been prepared and characterized on the basis of various spectroscopic techniques like electronic, EPR, FT-IR and 1H NMR studies, elemental analysis, magnetic properties and thermo-gravimetric analysis, and also by the aid of molar conductivity measurements. It is found that the Schiff base behaves as a monobasic tridentate, monobasic bidentate or dibasic tridentate ligand bonding to the metal ions via the oxygen atom of carbonyl oxygen atom in the enolic or ketonic form, azomethine nitrogen atom and/or oxygen atom of deprotonated phenolic hydroxyl group with 1 : 1 or 1 : 2 metal to ligand stoichiometry. Octahedral geometries have been assigned for Ni(II), Co(II), Mn(II), Fe(III) and Ru(III) complexes, tetragonally distorted octahedral geometry has been suggested for Cu(II) complexes, while square pyramidal geometry has been proposed for VO(II) complexes. The compounds were subjected to antimicrobial activity screening using Well diffusion method. Complexes (2), (8), (9), (10), (11), (13), (15) and (16) exhibit inhibitory effect towards fungus (Aspergillus niger) more than the parent ligand. However complexes (6), (2), (11), (12), (9), (16), (13), (5), (18), (15), (19), (8) and (7) are noticeable for antibacterial activity at the same concentration.
Keywords: Acetohydrazide, syntheses, spectroscopic studies, magnetism, biological activity
DOI: 10.3233/MGC-2012-0072
Journal: Main Group Chemistry, vol. 11, no. 3, pp. 189-204, 2012
