Synthesis, characterization and evaluation of in vitro antimicrobial activity of tri-n-butyltin(IV) complexes of para-azo-carboxylates derived from substituted anilines and 2,4-DNP
Affiliations: [a] Department of Chemistry, National Institute of Technology, Agartala, Jirania, Tripura (west), India | [b] Institute of Bioresources and Sustainable Development (IBSD), Takyelpat, Imphal, Manipur, India
Correspondence:
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Correspondence to: Keisham Surjit Singh, Department of Chemistry, National Institute of Technology, Agartala, Jirania, Tripura (west), India. [email protected]
Abstract: Tri-n-butyltin(IV) complexes of 4-{(E)-4-hydroxy-3-[(E)-(aryl)iminomethyl] phenyl diazenyl} -benzoic acids (L1 - 4HH′) and 4-((E)-(3-((E)-(2,4-dinitrophenyl) hydrazono) methyl)-4-hydroxy-phenyl) diazenyl) benzoic acid (L5HH′) have been synthesized by reacting 4-[(E)-2-(3-formyl-4-hydroxy-phenyl)-1-diazenyl] benzoic acid (LHH′) with bis-tri-n-butyltin(IV) oxide in anhydrous toluene, and then condensed with appropriate substituted anilines and 2,4-DNP (2,4-dinitro phenyl hydrazine) in ethanol. The complexes 1–5, have been characterized by UV, IR, 1H-, 13C-, 119Sn-NMR spectroscopy in combination with elemental analysis. The elemental analysis and spectroscopic studies of the complexes are consistent with the constitution of the expected products and suggested tetrahedral geometries in solution. The in vitro antimicrobial activities of the compounds were evaluated against various microbes and compared with standard drugs. The compounds were found to possess effective antimicrobial activity against the screened microbes.
