Affiliations: [a]
National Technical University “KharkivPolytechnic Institute” Frunze, Kharkiv, Ukraine
| [b]
Kharkiv National Medical University Nauki ave., Kharkiv, Ukraine
Correspondence:
[*]
Corresponding author: Igor Mikhailov, National Technical University “KharkivPolytechnic Institute”, Frunze,21 Kharkiv, 61002, Ukraine. Tel.: +38 057 7076 861; Fax: +38 057 7076 601; E-mail: [email protected].
Abstract: A method for urinary iodine diagnostics using a portable energy-dispersion X-ray fluorescent (EDXRF) spectrometer is proposed. The principle of the method consists in excitation of the sample atoms fluorescence by the energy spectrum intentionally formed from the spectrum of an X-ray tube using an optimized X-ray scheme. The optimization by the criterion of the minimum detection limit for L-series iodine fluorescence lines included the calculation of optimal atomic numbers for materials of a re-radiator and a filter, and their thicknesses, the collimation system parameters, and an X-ray tube voltage. Experimentally achieved detection limits were 45 and 75 μg/L by I-Lα and I-Lβ lines, respectively, at the theoretically extreme value 30 μg/L. This sensitivity is found to be sufficient for urinary iodine diagnostics in the range from 50 to 200 μg/L. The results obtained from different patients have shown the satisfactory convergence for the iodine concentration determination by Lα and I-Lβ fluorescence lines. The simple sample preparation procedure and comparably small sizes of the apparatus allows rapid researches directly in clinical settings.
