A modularly designed fluorescence molecular tomography system for multi-modality imaging

Article type: Research Article

Authors: Wang, Guohe | Zhang, Bin | Ding, Yichen | He, Yun | Chen, Jingsong | Lu, Yanye | Jiang, Xiaoyun | Shi, Junwei | Bai, Jing | Ren, Qiushi | Li, Changhui

Affiliations: Department of Biomedical Engineering, Peking University, Beijing, China | Department of Biomedical Engineering, Tsinghua University, Beijing, China

Note: [] Corresponding authors: Qiushi Ren, Changhui Li, Department of Biomedical Engineering, Peking University, Beijing 100871, China. E-mail: [email protected]; [email protected]

Abstract: Nowadays multi-modality imaging has gained great interest in biology research by offering complementary information. In this paper, a modularly designed fluorescence molecular tomography (FMT) system has been developed, which can be not only used as a standalone imaging device, but also feasibly integrated with other imaging modalities, such as X-ray computed tomography (X-CT), single photon emission computed tomography (SPECT) and positron emission tomography (PET), to perform multi-modality imaging in a sequential manner. The system rotates the CCD camera and the excitation light source in the vertical plane, while the animal is stationed on a horizontally moveable transparent animal holder at its natural prone position. FMT and other imaging modalities are co-registered automatically. Phantom and animal experiments have been carried out to demonstrate the performance of the system. The accurate results show that this innovative flexible FMT system has a great potential to be a powerful tool for the study of small animal disease models.

Keywords: Fluorescence molecular tomography, multi-modality imaging, fluorescence imaging

DOI: 10.3233/XST-150478

Journal: Journal of X-Ray Science and Technology, vol. 23, no. 2, pp. 147-156, 2015