Affiliations: Department of Nuclear Medicine, The First Affiliated
Hospital, Xiamen University, Xiamen, Fujian, China
Note: [] Corresponding author: Gui-Bing Chen, Department of Nuclear
Medicine, The First Affiliated Hospital, Xiamen University, Xiamen 361003,
Fujian, China. E-mail: [email protected]
Abstract: The aims of this study were to evaluate the diagnostic value of
adenosine thallium-201 myocardial perfusion imaging and to compare it with
exercise stress thallium-201 myocardial perfusion imaging for detecting
coronary artery disease (CAD) at an early stage. Forty-one patients suspected
with CAD were randomly divided into two groups. In Group 1 (n=21) adenosine
stress was undertaken; the exercise stress myocardial perfusion imaging was
performed in Group 2 (n=20). Coronary angiography (CAG) was performed in
each patient within 2 weeks before or after single photon emission computed
tomography (SPECT). Adenosine stress group vs. exercise stress group, the
sensitivity was 92.86% vs. 100.0%, specificity 57.14% vs. 60.0%,
positive predictive value 81.25% vs. 71.43%, negative predictive value
80.0% vs. 100.0%, accuracy 80.95% vs. 80.0% respectively. Detection
rates of vessels of coronary artery lesions were 66.67% in Group 1 and
72.22% in Group 2 (P> 0.05). The side effects were mild and transient.
Our results demonstrated that adenosine stress myocardial perfusion imaging is
a safe and reliable diagnostic method for an early stage of CAD. As a
comparative sensitivity and accuracy with exercise stress thallium-201
myocardial perfusion imaging, adenosine stress testing may provide a feasible
alternative pharmacological stress method in myocardial SPECT for detection of CAD.
