X-ray scattering tomography for biological applications

Article type: Research Article

Authors: Cong, W. | Wang, G.

Affiliations: Biomedical Imaging Division, VT-WFU School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA

Note: [] Corresponding author. E-mail: [email protected]

Abstract: The conventional attenuation contrast imaging does not yield satisfactory sensitivity and specificity for weakly absorbing media, such as biological soft tissues. The x-ray scattering offer an important contrast mechanism to reveal structural features and density fluctuation within an object. This scattering signal carries information at the molecular and supra-molecular level, and has a tremendous implication for biomedical and other applications. In this paper, we develop a scattering imaging approach to reconstruct the electron density distribution of an object and demonstrate its feasibility in the numerical simulation.

Keywords: X-ray scattering tomography, single scattering, electron density, compressive sensing

DOI: 10.3233/XST-2011-0288

Journal: Journal of X-Ray Science and Technology, vol. 19, no. 2, pp. 219-227, 2011